Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215

The reversible regulation of protein tyrosine phosphatase is an important mechanism in processing signal transduction and regulating cell cycle. Recent reports have shown that the active site cysteine residue, Cys215, can be reversibly oxidized to a cysteine sulfenic derivative (Denu and Tanner, 199...

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Published inBiochemistry (Easton) Vol. 38; no. 20; pp. 6699 - 6705
Main Authors Barrett, William C., DeGnore, Jon P., König, Simone, Fales, Henry M., Keng, Yen-Fang, Zhang, Zhong-Yin, Yim, Moon B., Chock, P. Boon
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 18.05.1999
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Abstract The reversible regulation of protein tyrosine phosphatase is an important mechanism in processing signal transduction and regulating cell cycle. Recent reports have shown that the active site cysteine residue, Cys215, can be reversibly oxidized to a cysteine sulfenic derivative (Denu and Tanner, 1998; Lee et al., 1998). We propose an additional modification that has implications for the in vivo regulation of protein tyrosine phosphatase 1B (PTP1B, EC 3.1.3.48):  the glutathionylation of Cys215 to a mixed protein disulfide. Treatment of PTP1B with diamide and reduced glutathione or with only glutathione disulfide (GSSG) results in a modification detected by mass spectrometry in which the cysteine residues are oxidized to mixed disulfides with glutathione. The activity is recovered by the addition of dithiothreitol, presumably by reducing the cysteine disulfides. In addition, inactivated PTP1B is reactivated enzymatically by the glutathione-specific dethiolase enzyme thioltransferase (glutaredoxin), indicating that the inactivated form of the phosphatase is a glutathionyl mixed disulfide. The cysteine sulfenic derivative can easily oxidize to its irreversible sulfinic and sulfonic forms and hinder the regulatory efficiency if it is not converted to a more stable and reversible end product such as a glutathionyl derivative. Glutathionylation of the cysteine sulfenic derivative will prevent the enzyme from further oxidation to its irreversible forms, and constitutes an efficient regulatory mechanism.
AbstractList The reversible regulation of protein tyrosine phosphatase is an important mechanism in processing signal transduction and regulating cell cycle. Recent reports have shown that the active site cysteine residue, Cys215, can be reversibly oxidized to a cysteine sulfenic derivative (Denu and Tanner, 1998; Lee et al., 1998). We propose an additional modification that has implications for the in vivo regulation of protein tyrosine phosphatase 1B (PTP1B, EC 3.1.3.48): the glutathionylation of Cys215 to a mixed protein disulfide. Treatment of PTP1B with diamide and reduced glutathione or with only glutathione disulfide (GSSG) results in a modification detected by mass spectrometry in which the cysteine residues are oxidized to mixed disulfides with glutathione. The activity is recovered by the addition of dithiothreitol, presumably by reducing the cysteine disulfides. In addition, inactivated PTP1B is reactivated enzymatically by the glutathione-specific dethiolase enzyme thioltransferase (glutaredoxin), indicating that the inactivated form of the phosphatase is a glutathionyl mixed disulfide. The cysteine sulfenic derivative can easily oxidize to its irreversible sulfinic and sulfonic forms and hinder the regulatory efficiency if it is not converted to a more stable and reversible end product such as a glutathionyl derivative. Glutathionylation of the cysteine sulfenic derivative will prevent the enzyme from further oxidation to its irreversible forms, and constitutes an efficient regulatory mechanism.
Author Fales, Henry M.
Zhang, Zhong-Yin
DeGnore, Jon P.
Chock, P. Boon
Keng, Yen-Fang
König, Simone
Barrett, William C.
Yim, Moon B.
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  surname: Fales
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  fullname: Zhang, Zhong-Yin
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  givenname: Moon B.
  surname: Yim
  fullname: Yim, Moon B.
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  givenname: P. Boon
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  fullname: Chock, P. Boon
BackLink https://www.ncbi.nlm.nih.gov/pubmed/10350489$$D View this record in MEDLINE/PubMed
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10.1074/jbc.272.33.20313
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Qin J. (bi990240vb00026/bi990240vb00026_1) 1997
Davis D. A. (bi990240vb00017/bi990240vb00017_1) 1997; 272
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Tonks N. K. (bi990240vb00004/bi990240vb00004_1) 1996
Barford D. (bi990240vb00008/bi990240vb00008_1) 1994
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Kosower N. S. (bi990240vb00027/bi990240vb00027_1) 1969
Davis D. A. (bi990240vb00016/bi990240vb00016_1) 1996
Ravichandran V. (bi990240vb00035/bi990240vb00035_1) 1994; 269
Zhang Z. Y. (bi990240vb00006/bi990240vb00006_1) 1994; 68
Hothersall J. S. (bi990240vb00033/bi990240vb00033_1) 1997; 322
Shifrin V. I. (bi990240vb00014/bi990240vb00014_1) 1997; 272
Carr A. C. (bi990240vb00031/bi990240vb00031_1) 1997; 327
Schuppe-Koistinen I. (bi990240vb00036/bi990240vb00036_1) 1994; 221
Hecht D. (bi990240vb00001/bi990240vb00001_1) 1992
Wink D. A. (bi990240vb00032/bi990240vb00032_1) 1997; 272
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Snippet The reversible regulation of protein tyrosine phosphatase is an important mechanism in processing signal transduction and regulating cell cycle. Recent reports...
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SubjectTerms Amino Acid Sequence
Binding Sites
Cysteine - chemistry
Cysteine - metabolism
Dithionitrobenzoic Acid - chemistry
Electrophoresis, Polyacrylamide Gel
Enzyme Activation
Glutathione - chemistry
Glutathione - metabolism
Glutathione - physiology
Glutathione Disulfide - chemistry
Glutathione Disulfide - metabolism
Glutathione Disulfide - physiology
Humans
Kinetics
Mass Spectrometry
Molecular Sequence Data
Oxidation-Reduction
Protein Tyrosine Phosphatases - antagonists & inhibitors
Protein Tyrosine Phosphatases - chemistry
Protein Tyrosine Phosphatases - metabolism
Titrimetry
Title Regulation of PTP1B via Glutathionylation of the Active Site Cysteine 215
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