The gut microbiome in end-stage lung disease and lung transplantation

• Published in: mSystems Vol. 9; no. 6; p. e0131223
• Main Authors: Zhang, Shuyan, Swarte, J Casper, Gacesa, Ranko, Knobbe, Tim J, Kremer, Daan, Jansen, Bernadien H, de Borst, Martin H, Harmsen, Hermie J M, Erasmus, Michiel E, Verschuuren, Erik A M, Bakker, Stephan J L, Gan, C Tji, Weersma, Rinse K, Björk, Johannes R
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 18.06.2024
• Subjects: Adult; Aged; Allografts; Antibiotics; Biobanks; Chronic obstructive pulmonary disease; Cohort analysis; Cystic fibrosis; Drug resistance; Dysbacteriosis; dysbiosis; Dysbiosis - microbiology; end-stage lung disease; End-stage renal disease; Feces; Feces - microbiology; Female; Gastrointestinal Microbiome; gut microbiome; Human Microbiome; Humans; Immunosuppressive agents; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; immunosuppressive medication; Intestinal microflora; Kidney diseases; Kidney transplantation; Liver diseases; Liver transplantation; Liver transplants; Lung diseases; Lung Diseases - microbiology; Lung Diseases - surgery; Lung transplantation; Lung Transplantation - adverse effects; Lung transplants; Male; Metabolism; Metabolites; Metagenomics; Microbiomes; Middle Aged; Research Article; Veganism; Virulence; end-stage lung disease; lung transplantation; gut microbiome; immunosuppressive medication; dysbiosis

Gut dysbiosis has been associated with impaired outcomes in liver and kidney transplant recipients, but the gut microbiome of lung transplant recipients has not been extensively explored. We assessed the gut microbiome in 64 fecal samples from end-stage lung disease patients before transplantation a...