New Antitumor-Active Azole-Bridged Dinuclear Platinum(II) Complexes:  Synthesis, Characterization, Crystal Structures, and Cytotoxic Studies

• Published in: Inorganic chemistry Vol. 39; no. 19; pp. 4230 - 4236
• Main Authors: Komeda, Seiji, Lutz, Martin, Spek, Anthony L, Chikuma, Masahiko, Reedijk, Jan
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.09.2000
• Subjects: Antineoplastic Agents - chemical synthesis; Azoles - chemical synthesis; Azoles - chemistry; Azoles - toxicity; Bridged-Ring Compounds - chemical synthesis; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - toxicity; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Platinum Compounds - chemical synthesis; Platinum Compounds - chemistry; Platinum Compounds - toxicity; Stereoisomerism; Structure-Activity Relationship; Tumor Cells, Cultured; X-Ray Diffraction

Three new derivatives of the cytotoxic azole-bridged dinuclear platinum(II) complex [{cis-Pt(NH3)2}2(μ-OH)(μ-pz)][NO3]2 (1) have been prepared and structurally characterized. Their formulas are [{cis-Pt(NH3)2}2(μ-OH)(μ-1,2,3-ta)][NO3]2 (2) (1,2,3-ta = 1,2,3-triazolate), [{Pt(R,R-dach)}(μ-OH)(μ-pz){P...