Photoaffinity, biotinyl, and iodo analogs as probes for vasotocin receptors

• Published in: Journal of medicinal chemistry Vol. 32; no. 11; pp. 2432 - 2435
• Main Authors: Buku, Angeliki, Gazis, Diana, Eggena, Patrick
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 01.11.1989
• Subjects: Affinity Labels; Animals; Anura; Biotin; Chemistry; Exact sciences and technology; Iodine; Organic chemistry; Peptides; Preparations and properties; Rats; Receptors, Angiotensin - metabolism; Receptors, Vasopressin; vasopressin; Vasopressins; Vasotocin - analogs & derivatives; Vasotocin - chemical synthesis; Nonapeptide; Solid phase; Antidiuretic; Cyclic peptides; Biological activity

Vasotocin (AVT) analogues with tyrosine or phenylalanine in position 9, i.e., [9-tyrosine]AVT, [2-phenylalanine,-9-tyrosine]AVT, and 1-desamino[9-(p-aminophenylalanine)]AVT, were synthesized by the solid-phase method. These compounds showed a high biological activity in the hydroosmotic toad bladder...