Chiral Dicarboxamide Scaffolds Containing a Sulfiliminyl Moiety as Potential Ryanodine Receptor Activators

• Published in: Journal of agricultural and food chemistry Vol. 62; no. 27; pp. 6269 - 6277
• Main Authors: Zhou, Sha, Jia, Zhehui, Xiong, Lixia, Yan, Tao, Yang, Na, Wu, Guiping, Song, Haibin, Li, Zhengming
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 09.07.2014; Amer Chemical Soc
• Subjects: Agriculture; Agriculture, Multidisciplinary; Animals; biological assessment; Calcium Channel Agonists - chemical synthesis; Calcium Channel Agonists - chemistry; Calcium Channel Agonists - pharmacology; carbon; Chemistry; Chemistry, Applied; Diamines - chemistry; Diamines - pharmacology; Drug Design; flubendiamide; Food Science & Technology; Insect Proteins - agonists; Insect Proteins - chemistry; Insect Proteins - metabolism; insecticidal properties; insecticides; Insecticides - chemical synthesis; Insecticides - chemistry; Insecticides - pharmacology; Larva - chemistry; Larva - drug effects; Larva - metabolism; lethal concentration 50; Life Sciences & Biomedicine; Molecular Structure; Moths - chemistry; Moths - drug effects; Moths - metabolism; Mythimna separata; nuclear magnetic resonance spectroscopy; Physical Sciences; Plutella xylostella; polarimetry; Ryanodine Receptor Calcium Release Channel - chemistry; Ryanodine Receptor Calcium Release Channel - metabolism; Science & Technology; Stereoisomerism; stereoisomers; Structure-Activity Relationship; sulfur; toxicity; optically active; insecticidal activity; sulfiliminyl; ANTHRANILIC DIAMIDES

To search for new environmentally benign insecticides with high activity, low toxicity, and low residue, novel chiral configurations introduced into dicarboxamide scaffolds containing N-cyano sulfiliminyl moieties were first studied. Four series of phthalamides with sulfur-containing side chains wer...