Sources of hydrogen abstraction by activated neocarzinostatin chromophore
Activation of the enediyne neocarzinostatin chromophore (NCS-Chrom) by thiol addition at C-12 generates a diradical species with radical centers at C-2 and C-6, which abstract hydrogens from deoxyribose in the minor groove of DNA. Since hydrogen abstraction from DNA accounts for only part of the hyd...
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Published in | Biochemistry (Easton) Vol. 32; no. 14; pp. 3611 - 3616 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
Washington, DC
American Chemical Society
13.04.1993
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Subjects | |
Online Access | Get full text |
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