Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates - Staben, Leanna R; Chen, Jinhua; Cruz-Chuh, Josefa dela; del Rosario, Geoff; Go, Mary Ann; Guo, Jun; Khojasteh, S. Cyrus; Kozak, Katherine R; Li, Guangmin; Ng, Carl; Lewis Phillips, Gail D; Pillow, Thomas H; et al. (Journal of medicinal chemistry, 2020)
Keywords: Benzodiazepines - chemistry; Binding Sites; Cell Line, Tumor; Cell Proliferation - drug effects; Chemical Phenomena; Chemistry, Medicinal; Dimerization; DNA - chemistry; DNA - metabolism; Humans; Immunoconjugates - adverse effects; Immunoconjugates - chemistry; Immunoconjugates - metabolism; Immunoconjugates - pharmacology; Life Sciences & Biomedicine; Models, Molecular; Nucleic Acid Conformation; Pharmacology & Pharmacy; Pyrroles - chemistry; Safety; Science & Technology; CANCER-CELLS; TARGET; DIMER; POTENCY; DNA; CROSS-LINKING; RELEASE