Design, Synthesis, and Evaluation of Fluorinated Radioligands for Myelin Imaging

• Published in: Journal of medicinal chemistry Vol. 59; no. 8; pp. 3705 - 3718
• Main Authors: Tiwari, Anand Dev, Wu, Chunying, Zhu, Junqing, Zhang, Sheng, Zhu, Jinle, Wang, William R, Zhang, Jinming, Tatsuoka, Curtis, Matthews, Paul M, Miller, Robert H, Wang, Yanming
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 28.04.2016; Amer Chemical Soc
• Subjects: Animals; Autoradiography; Chemistry, Medicinal; Drug Design; Fluorine Radioisotopes - chemistry; Life Sciences & Biomedicine; Mice; Multimodal Imaging; Myelin Sheath - metabolism; Pharmacology & Pharmacy; Positron-Emission Tomography; Science & Technology; Structure-Activity Relationship; Tomography, X-Ray Computed; NERVOUS-SYSTEM; POSITRON-EMISSION-TOMOGRAPHY; MULTIPLE-SCLEROSIS; WHITE-MATTER; DEMYELINATION; DISEASE; SPINAL-CORD; REMYELINATION; RAT MODEL; BRAIN

Myelination is one of the fundamental processes in vertebrates. A major challenge is to quantitatively image myelin distribution in the central nervous system. For this reason, we designed and synthesized a series of fluorinated radioligands that can be radiolabeled as radiotracers for positron emis...