Identification and Preclinical Development of a 2,5,6-Trisubstituted Fluorinated Pyridine Derivative as a Radioligand for the Positron Emission Tomography Imaging of Cannabinoid Type 2 Receptors - Haider, Achi; Gobbi, Luca; Kretz, Julian; Ullmer, Christoph; Brink, Andreas; Honer, Michael; Woltering, Thomas J.; Muri, Dieter; Iding, Hans; Bürkler, Markus; Binder, Martin; Bartelmus, Christian; et al. (Journal of medicinal chemistry, 2020)
Keywords: Animals; Brain - diagnostic imaging; Chemistry, Medicinal; Fluorine Radioisotopes - chemistry; Humans; Life Sciences & Biomedicine; Ligands; Male; Molecular Docking Simulation; Molecular Structure; Pharmacology & Pharmacy; Positron-Emission Tomography; Pyridines - chemical synthesis; Pyridines - pharmacokinetics; Pyridines - pharmacology; Radiopharmaceuticals - chemical synthesis; Radiopharmaceuticals - pharmacokinetics; Radiopharmaceuticals - pharmacology; Rats, Wistar; Receptor, Cannabinoid, CB2 - metabolism; Science & Technology; Spinal Cord - diagnostic imaging; Spleen - diagnostic imaging; Structure-Activity Relationship; Tritium - chemistry; SYSTEM; PET RADIOLIGANDS; CB2 RECEPTORS; PHARMACOLOGY; HIGH-AFFINITY; IN-VIVO EVALUATION; EXPRESSION; BINDING; DISCOVERY; LIPOPHILICITY