Regulation of the Biological Functions of Osteoblasts and Bone Formation by Zn-Incorporated Coating on Microrough Titanium

• Published in: ACS applied materials & interfaces Vol. 6; no. 18; pp. 16426 - 16440
• Main Authors: Shen, Xinkun, Hu, Yan, Xu, Gaoqiang, Chen, Weizhen, Xu, Kui, Ran, Qichun, Ma, Pingping, Zhang, Yarong, Li, Jinghua, Cai, Kaiyong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 24.09.2014
• Subjects: acid phosphatase; adhesion; alkaline phosphatase; Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Anti-Bacterial Agents - toxicity; bacteria; bone formation; cell differentiation; Cell Line; cell proliferation; Cell Survival - drug effects; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacology; Coated Materials, Biocompatible - toxicity; coatings; contact angle; Femur - surgery; gene expression; in vitro studies; in vivo studies; ions; Mice; micro-computed tomography; mineralization; orthopedics; osteoblasts; Osteoblasts - cytology; Osteoblasts - drug effects; Osteoblasts - metabolism; Osteoblasts - transplantation; osteoclasts; Osteogenesis - drug effects; prostheses; Pseudomonas aeruginosa; Rabbits; Rats; scanning electron microscopy; sol-gel processing; Staphylococcus aureus; Surface Properties; titanium; Titanium - chemistry; Titanium - pharmacology; Titanium - toxicity; X-ray diffraction; X-ray photoelectron spectroscopy; zinc; Zinc - chemistry; Zinc - pharmacology; Zinc - toxicity; zinc oxide; in vivo; osteoblasts; osteogenesis; zinc; titanium

To improve the biological performance of titanium implant, a series of Zn-incorporated coatings were fabricated on the microrough titanium (Micro-Ti) via sol–gel method by spin-coating technique. The successful fabrication of the coating was verified by combined techniques of scanning electron micro...