Three-Dimensional Nanostructured Architectures Enable Efficient Neural Differentiation of Mesenchymal Stem Cells via Mechanotransduction

• Published in: Nano letters Vol. 18; no. 11; pp. 7188 - 7193
• Main Authors: Poudineh, Mahla, Wang, Zongjie, Labib, Mahmoud, Ahmadi, Moloud, Zhang, Libing, Das, Jagotamoy, Ahmed, Sharif, Angers, Stephane, Kelley, Shana O
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 14.11.2018
• Subjects: Cell Culture Techniques - methods; Cell Differentiation; Humans; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - metabolism; Nanostructures - chemistry; Neurons - cytology; Neurons - metabolism; Time Factors; nanostructured architectures; Stem cell differentiation; cell morphology; neural differentiation

Cell morphology and geometry affect cellular processes such as stem cell differentiation, suggesting that these parameters serve as fundamental regulators of biological processes within the cell. Hierarchical architectures featuring micro- and nanotopographical features therefore offer programmable...