Copper-Mediated Direct Aryloxylation of Benzamides Assisted by an N,O‑Bidentate Directing Group

• Published in: Organic letters Vol. 16; no. 4; pp. 1104 - 1107
• Main Authors: Hao, Xin-Qi, Chen, Li-Juan, Ren, Baozeng, Li, Liu-Yan, Yang, Xin-Yan, Gong, Jun-Fang, Niu, Jun-Long, Song, Mao-Ping
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 21.02.2014; Amer Chemical Soc
• Subjects: benzamides; benzoic acids; chemical reactions; chemical structure; Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; BIDENTATE-CHELATION ASSISTANCE; FUNCTIONALIZATION; ACID DERIVATIVES; CROSS-COUPLING REACTIONS; ACTIVATION; DIRECT ARYLATION; AROMATIC AMIDES; ARYL; DIARYL ETHERS; C-H BONDS

Copper-mediated selective mono- or diaryloxylation of benzamides has been achieved by using 2-aminopyridine 1-oxide as a new and removable N,O-bidentate directing group. The reaction system shows a broad substrate scope and provides a straightforward way for the synthesis of mono- and diaryloxylated...