Magnetic Resonance Imaging Quantification of Fasted State Colonic Liquid Pockets in Healthy Humans

• Published in: Molecular pharmaceutics Vol. 14; no. 8; pp. 2629 - 2638
• Main Authors: Murray, Kathryn, Hoad, Caroline L, Mudie, Deanna M, Wright, Jeff, Heissam, Khaled, Abrehart, Nichola, Pritchard, Susan E, Al Atwah, Salem, Gowland, Penny A, Garnett, Martin C, Amidon, Gregory E, Spiller, Robin C, Amidon, Gordon L, Marciani, Luca
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.08.2017
• Subjects: Adult; Colon - diagnostic imaging; Colon - metabolism; Fasting - metabolism; Female; Gastric Mucosa - metabolism; Gastrointestinal Tract - diagnostic imaging; Gastrointestinal Tract - metabolism; Healthy Volunteers; Humans; Intestine, Small - diagnostic imaging; Intestine, Small - metabolism; Magnetic Resonance Imaging - methods; Male; Stomach - diagnostic imaging; Water - metabolism; Young Adult; controlled release; intestinal water; MRI; bioperformance; dissolution; large bowel; delayed release

The rate and extent of drug dissolution and absorption from solid oral dosage forms is highly dependent on the volume of liquid in the gastrointestinal tract (GIT). However, little is known about the time course of GIT liquid volumes after drinking a glass of water (8 oz), particularly in the colon,...