Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein

• Published in: Nano letters Vol. 20; no. 2; pp. 1089 - 1100
• Main Authors: Huang, Yao-Shen, Fan, Ching-Hsiang, Hsu, Ning, Chiu, Nai-Hua, Wu, Chun-Yao, Chang, Chu-Yuan, Wu, Bing-Huan, Hong, Shi-Rong, Chang, Ya-Chu, Yan-Tang Wu, Anthony, Guo, Vanessa, Chiang, Yueh-Chen, Hsu, Wei-Chia, Chen, Linyi, Pin-Kuang Lai, Charles, Yeh, Chih-Kuang, Lin, Yu-Chun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 12.02.2020
• Subjects: Animals; Brain - metabolism; Echolocation; Hearing - genetics; Hearing - physiology; Humans; Mice; Molecular Motor Proteins - chemistry; Molecular Motor Proteins - genetics; Neurons - chemistry; Neurons - metabolism; Protein Engineering - methods; Ultrasonic Waves; neuromodulation; Sonogenetics; mammalian cells; focused ultrasound

Biomolecules that respond to different external stimuli enable the remote control of genetically modified cells. We report herein a sonogenetic approach that can manipulate target cell activities by focused ultrasound stimulation. This system requires an ultrasound-responsive protein derived from an...