Nanopore Stochastic Detection: Diversity, Sensitivity, and Beyond

• Published in: Accounts of chemical research Vol. 46; no. 12; pp. 2867 - 2877
• Main Authors: Wang, Guihua, Wang, Liang, Han, Yujing, Zhou, Shuo, Guan, Xiyun
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 17.12.2013
• Subjects: Amplification; Biosensing Techniques - standards; Bonding; Covalence; Deoxyribonucleic acid; Folding; Limit of Detection; Nanopores; Nanostructure; Peptides - analysis; Peptides - chemistry; Porosity; Stochasticity

Nanopore sensors have emerged as a label-free and amplification-free technique for measuring single molecules. First proposed in the mid-1990s, nanopore detection takes advantage of the ionic current modulations produced by the passage of target analytes through a single nanopore at a fixed applied...