Design, Synthesis, and Evaluation of Orally Available Clioquinol-Moracin M Hybrids as Multitarget-Directed Ligands for Cognitive Improvement in a Rat Model of Neurodegeneration in Alzheimer’s Disease - Wang, Zhiren; Wang, Yali; Wang, Bo; Li, Wenrui; Huang, Ling; Li, Xingshu (Journal of medicinal chemistry, 2015)
Keywords: Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer Disease - physiopathology; Amyloid beta-Peptides - antagonists & inhibitors; Amyloid beta-Peptides - metabolism; Animals; Antioxidants - chemistry; Antioxidants - therapeutic use; Benzofurans - chemistry; Benzofurans - therapeutic use; Chemistry, Medicinal; Clioquinol - analogs & derivatives; Clioquinol - therapeutic use; Cognition - drug effects; Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism; Inflammation - drug therapy; Inflammation - metabolism; Inflammation - physiopathology; Life Sciences & Biomedicine; Ligands; Male; Memory - drug effects; Models, Molecular; Neurons - drug effects; Neurons - metabolism; Neurons - pathology; Neuroprotective Agents - chemistry; Neuroprotective Agents - therapeutic use; Pharmacology & Pharmacy; Phosphodiesterase 4 Inhibitors - chemistry; Phosphodiesterase 4 Inhibitors - therapeutic use; Protein Aggregates - drug effects; Rats; Rats, Wistar; Resorcinols - chemistry; Resorcinols - therapeutic use; Science & Technology; TARGET; AMYLOID-BETA PEPTIDE; PHOSPHODIESTERASE-4 INHIBITORS; SMALL MOLECULES; ACETYLCHOLINESTERASE; ANTIOXIDANT; BIOLOGICAL EVALUATION; HIGHLY POTENT; DERIVATIVES; AGGREGATION