Poly(ethyl glyoxylate)-Poly(ethylene oxide) Nanoparticles: Stimuli-Responsive Drug Release via End-to-End Polyglyoxylate Depolymerization

• Published in: Molecular pharmaceutics Vol. 14; no. 8; pp. 2548 - 2559
• Main Authors: Fan, Bo, Gillies, Elizabeth R
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.08.2017
• Subjects: Curcumin - chemistry; Drug Carriers - chemistry; Drug Delivery Systems - methods; Drug Liberation; Hydrogen Peroxide - chemistry; Methylmethacrylates - chemistry; Nanoparticles - chemistry; Polyethylene Glycols - chemistry; self-immolative; drug delivery; depolymerization; stimuli-responsive; polyglyoxylate

The ability to disrupt polymer assemblies in response to specific stimuli provides the potential to release drugs selectively at certain sites or conditions in vivo. However, most stimuli-responsive delivery systems require many stimuli-initiated events to release drugs. “Self-immolative polymers” o...