A Review of Progress in Histone Deacetylase 6 Inhibitors Research: Structural Specificity and Functional Diversity

• Published in: Journal of medicinal chemistry Vol. 64; no. 3; pp. 1362 - 1391
• Main Authors: Zhang, Xin-Hui, Qin-Ma, Wu, Hui-Pan, Khamis, Mussa Yussuf, Li, Yi-Han, Ma, Li-Ying, Liu, Hong-Min
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.02.2021
• Subjects: Animals; Histone Deacetylase 6 - antagonists & inhibitors; Histone Deacetylase Inhibitors - chemistry; Histone Deacetylase Inhibitors - pharmacology; Histone Deacetylase Inhibitors - therapeutic use; Histone Deacetylases - chemistry; Humans; Models, Molecular; Structure-Activity Relationship

Histone deacetylases (HDACs) are essential for maintaining homeostasis by catalyzing histone deacetylation. Aberrant expression of HDACs is associated with various human diseases. Although HDAC inhibitors are used as effective chemotherapeutic agents in clinical practice, their applications remain l...