Lipid-AuNPs@PDA Nanohybrid for MRI/CT Imaging and Photothermal Therapy of Hepatocellular Carcinoma

• Published in: ACS applied materials & interfaces Vol. 6; no. 16; pp. 14266 - 14277
• Main Authors: Zeng, Yongyi, Zhang, Da, Wu, Ming, Liu, Ying, Zhang, Xiang, Li, Ling, Li, Zheng, Han, Xiao, Wei, Xueyong, Liu, Xiaolong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.08.2014
• Subjects: absorbance; aqueous solutions; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - therapy; Cell Death - drug effects; Cell Death - radiation effects; Cell Line; cytotoxicity; Diagnostic Imaging - methods; Gadolinium - chemistry; Gold - chemistry; HeLa Cells; Hep G2 Cells; hepatoma; human cell lines; Humans; image analysis; Indocyanine Green - chemistry; Indoles - chemistry; irradiation; lipids; Lipids - chemistry; Liver Neoplasms - diagnosis; Liver Neoplasms - therapy; magnetic resonance imaging; Magnetic Resonance Imaging - methods; Metal Nanoparticles - chemistry; nanogold; nanoparticles; neoplasm cells; Phototherapy - methods; Polymers - chemistry; therapeutics; tomography; Tomography, X-Ray Computed - methods; X-radiation; polydopamine; lactobionic acid; targeted photothermal therapy; dual-mode imaging; AuNPs

Multifunctional theranostic nanoparticles represent an emerging agent with the potential to offer extremely sensitive diagnosis and targeted cancer therapy. Herein, we report the synthesis and characterization of a multifunctional theranostic agent (referred to as LA-LAPNHs) for targeted magnetic re...