Small Molecule Allosteric Modulators of G‑Protein-Coupled Receptors: Drug–Target Interactions

• Published in: Journal of medicinal chemistry Vol. 62; no. 1; pp. 24 - 45
• Main Authors: Lu, Shaoyong, Zhang, Jian
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 10.01.2019

G-protein-coupled receptors (GPCRs) are the largest class of signaling receptors that are most frequently targeted by therapeutic drugs. Allosteric modulators bound to GPCRs at allosteric sites provide the potential for differential selectivity and improved safety compared with traditional orthoster...