Iridium-Catalyzed Asymmetric Hydrogenation of Unsaturated Carboxylic Acids

• Published in: Accounts of chemical research Vol. 50; no. 4; pp. 988 - 1001
• Main Authors: Zhu, Shou-Fei, Zhou, Qi-Lin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 18.04.2017

Chiral carboxylic acid moieties are widely found in pharmaceuticals, agrochemicals, flavors, fragrances, and health supplements. Although they can be synthesized straightforwardly by transition-metal-catalyzed enantioselective hydrogenation of unsaturated carboxylic acids, because the existing chira...