Poly(2-oxazoline) Hydrogels for Controlled Fibroblast Attachment

Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of this study was to investigate the attachment of cells onto hydrogels prepared from poly(2-oxazoline)s selectively functionalized with cell adhes...

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Published inBiomacromolecules Vol. 14; no. 8; pp. 2724 - 2732
Main Authors Farrugia, Brooke L, Kempe, Kristian, Schubert, Ulrich S, Hoogenboom, Richard, Dargaville, Tim R
Format Journal Article
LanguageEnglish
Published Washington, DC American Chemical Society 12.08.2013
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Abstract Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of this study was to investigate the attachment of cells onto hydrogels prepared from poly(2-oxazoline)s selectively functionalized with cell adhesion motifs. A water-soluble macromer based on the microwave-assisted cationic ring-opening polymerization of 2-methyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline was functionalized with the peptide CRGDSG or controls using thiol–ene photochemistry followed by facile cross-linking in the presence of a dithiol cross-linker. The growth of human fibroblasts on the hydrogel surfaces was dictated by the structure and amount of incorporated peptide. Controls without any peptide showed resistance to cellular attachment. The benignity of the cross-linking conditions was demonstrated by the incorporation of fibroblasts within the hydrogels to produce three-dimensional cell–polymer constructs.
AbstractList Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of this study was to investigate the attachment of cells onto hydrogels prepared from poly(2-oxazoline)s selectively functionalized with cell adhesion motifs. A water-soluble macromer based on the microwave-assisted cationic ring-opening polymerization of 2-methyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline was functionalized with the peptide CRGDSG or controls using thiol-ene photochemistry followed by facile cross-linking in the presence of a dithiol cross-linker. The growth of human fibroblasts on the hydrogel surfaces was dictated by the structure and amount of incorporated peptide. Controls without any peptide showed resistance to cellular attachment. The benignity of the cross-linking conditions was demonstrated by the incorporation of fibroblasts within the hydrogels to produce three-dimensional cell-polymer constructs.
Author Schubert, Ulrich S
Dargaville, Tim R
Farrugia, Brooke L
Kempe, Kristian
Hoogenboom, Richard
AuthorAffiliation Ghent University
Friedrich Schiller University Jena
Queensland University of Technology
AuthorAffiliation_xml – name: Queensland University of Technology
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  surname: Kempe
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  givenname: Ulrich S
  surname: Schubert
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  email: t.dargaville@qut.edu.au, ulrich.schubert@uni-jena.de, richard.hoogenboom@ugent.be
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Issue 8
Keywords Cationic copolymerization
Encapsulation
Photochemical crosslinking
Peptides
Tissue engineering
Photochemical reaction
Experimental study
Sulfur copolymer
Lateral group
Colloidal gel
Chemical modification
Mercaptoalcohol
Preparation
Cell adhesion
Addition reaction
Biomaterial
Ethyleneimine derivative copolymer
Ring opening copolymerization
Fibroblast
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Snippet Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of...
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SubjectTerms Amino Acid Sequence
Applied sciences
Biological and medical sciences
Cell Adhesion
Cell Shape
Cells, Cultured
Exact sciences and technology
Fibroblasts - physiology
Humans
Hydrogels - chemical synthesis
Hydrogels - chemistry
Medical sciences
Oligopeptides - chemistry
Organic polymers
Oxazoles - chemistry
Physicochemistry of polymers
Properties and characterization
Solution and gel properties
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology. Biomaterials. Equipments
Title Poly(2-oxazoline) Hydrogels for Controlled Fibroblast Attachment
URI http://dx.doi.org/10.1021/bm400518h
https://www.ncbi.nlm.nih.gov/pubmed/23844837
https://search.proquest.com/docview/1420163374
https://search.proquest.com/docview/1524423410
Volume 14
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