Formation of Pearl-Necklace Monomorphic G-Quadruplexes in the Human CEB25 Minisatellite

• Published in: Journal of the American Chemical Society Vol. 134; no. 13; pp. 5807 - 5816
• Main Authors: Amrane, Samir, Adrian, Michael, Heddi, Brahim, Serero, Alexandre, Nicolas, Alain, Mergny, Jean-Louis, Phan, Anh Tuân
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.04.2012
• Subjects: alleles; Base Pairing; Base Sequence; enthalpy; G-Quadruplexes; Genetic Loci - genetics; germ cells; heterozygosity; human population; Humans; loci; melting point; Mendelian inheritance; Minisatellite Repeats - genetics; Models, Molecular; nuclear magnetic resonance spectroscopy; Nucleic Acid Denaturation; potassium; Potassium - chemistry; Solutions; tandem repeat sequences; Thermodynamics; Transition Temperature

CEB25 is a human minisatellite locus, composed of slightly polymorphic 52-nucleotide (nt) tandem repeats. Genetically, most if not all individuals of the human population are heterozygous, carrying alleles ranging from 0.5 to 20 kb, maintained by mendelian inheritance but also subject to germline in...