Cryptic environmental conjugative plasmid recruits a novel hybrid transposon resulting in a new plasmid with higher dispersion potential

• Published in: mSphere Vol. 9; no. 6; p. e0025224
• Main Authors: Muñoz-Gutiérrez, Iván, Cantu, Luis, Shanahan, Jack, Girguis, Miray, de la Cruz, Marlene, Mota-Bravo, Luis
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 25.06.2024
• Subjects: Antibiotic resistance; Antibiotics; Bacteria; Conjugation; criptic plasmid; Drug resistance; E coli; Genes; Genomes; Multidrug resistance; Plasmids; Public Health; Research Article; Sulfonamides; Transposons; Trimethoprim; Baton Rouge Louisiana; United States > US; criptic plasmid; antibiotic resistance; transposons

Cryptic conjugative plasmids lack antibiotic-resistance genes (ARGs). These plasmids can capture ARGs from the vast pool of the environmental metagenome, but the mechanism to recruit ARGs remains to be elucidated. To investigate the recruitment of ARGs by a cryptic plasmid, we sequenced and conducte...