A Manganese Alternative to Gadolinium for MRI Contrast

• Published in: Journal of the American Chemical Society Vol. 137; no. 49; pp. 15548 - 15557
• Main Authors: Gale, Eric M, Atanasova, Iliyana P, Blasi, Francesco, Ay, Ilknur, Caravan, Peter
• Format: Journal Article
• Language: English
• Published: WASHINGTON American Chemical Society 16.12.2015; Amer Chemical Soc
• Subjects: animal models; blood plasma; chelates; chelating agents; Chemistry; Chemistry, Multidisciplinary; computed tomography; Contrast Media - chemistry; Coordination Complexes - chemical synthesis; Coordination Complexes - chemistry; dissociation; fibrin; gadolinium; Gadolinium - chemistry; image analysis; kidney diseases; Magnetic Resonance Imaging; manganese; Manganese - chemistry; metabolites; Molecular Structure; patients; Physical Sciences; Science & Technology; thrombosis; United States; zinc; United States; ANGIOGRAPHY; DENTATE NUCLEUS; EP-2104R; AGENTS; RELAXIVITY; HIGH SIGNAL INTENSITY; MN2+ COMPLEXES; METAL-COMPLEXES; NEPHROGENIC SYSTEMIC FIBROSIS; FIBRIN

Contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI) are routinely used to diagnose soft tissue and vascular abnormalities. However, safety concerns limit the use of iodinated and gadolinium (Gd)-based CT and MRI contrast media in renally compromised patients. With an esti...