Drug-Triggered and Cross-Linked Self-Assembling Nanofibrous Hydrogels

• Published in: Journal of the American Chemical Society Vol. 137; no. 14; pp. 4823 - 4830
• Main Authors: Kumar, Vivek A, Shi, Siyu, Wang, Benjamin K, Li, I-Che, Jalan, Abhishek A, Sarkar, Biplab, Wickremasinghe, Navindee C, Hartgerink, Jeffrey D
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.04.2015
• Subjects: Animals; anions; bioavailability; Cell Line; crosslinking; cytokines; Delayed-Action Preparations; Drug Carriers - chemistry; Drug Liberation; drugs; Female; growth factors; heparin; Humans; hydrogels; Hydrogels - chemistry; loss modulus; Models, Molecular; Molecular Conformation; nanofibers; Nanofibers - chemistry; Oligopeptides - chemistry; Pharmaceutical Preparations - chemistry; phenotype; phosphates; Rats; rheometry; suramin; transmission electron microscopy; ultraviolet-visible spectroscopy

Self-assembly of multidomain peptides (MDP) can be tailored to carry payloads that modulate the extracellular environment. Controlled release of growth factors, cytokines, and small-molecule drugs allows for unique control of in vitro and in vivo responses. In this study, we demonstrate this process...