Structure and Function of Malic Enzymes, A New Class of Oxidative Decarboxylases

• Published in: Biochemistry (Easton) Vol. 42; no. 44; pp. 12721 - 12733
• Main Authors: Chang, Gu-Gang, Tong, Liang
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.11.2003
• Subjects: Amino Acid Sequence; Animals; Carboxy-Lyases - chemistry; Carboxy-Lyases - classification; Carboxy-Lyases - metabolism; Humans; Malate Dehydrogenase - chemistry; Malate Dehydrogenase - classification; Malate Dehydrogenase - metabolism; Molecular Sequence Data; Oxidation-Reduction; Sequence Homology, Amino Acid; Structure-Activity Relationship

Malic enzyme is a tetrameric protein with double dimer structure in which the dimer interface is more intimately contacted than the tetramer interface. Each monomeric unit of the enzyme is composed of four structural domains, which show a different folding topology from those of the other oxidative...