Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death
Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dyi...
Saved in:
| Published in | Bioconjugate chemistry Vol. 27; no. 2; pp. 363 - 375 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
17.02.2016
Amer Chemical Soc |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1043-1802 1520-4812 1520-4812 |
| DOI | 10.1021/acs.bioconjchem.5b00447 |
Cover
| Abstract | Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich membranes and act as cell death molecular imaging agents. However, there is a need to improve in vivo imaging performance by selectively increasing target affinity and decreasing off-target accumulation. This present study compared the cell death targeting ability of two new deep-red fluorescent probes containing phenoxide-bridged Zn2BDPA complexes. One probe was a bivalent version of the other and associated more strongly with PS-rich liposome membranes. However, the bivalent probe exhibited self-quenching on the membrane surface, so the monovalent version produced brighter micrographs of dead and dying cells in cell culture and also better fluorescence imaging contrast in two living animal models of cell death (rat implanted tumor with necrotic core and mouse thymus atrophy). An 111In-labeled radiotracer version of the monovalent probe also exhibited selective cell death targeting ability in the mouse thymus atrophy model, with relatively high amounts detected in dead and dying tissue and low off-target accumulation in nonclearance organs. The in vivo biodistribution profile is the most favorable yet reported for a Zn2BDPA complex; thus, the monovalent phenoxide-bridged Zn2BDPA scaffold is a promising candidate for further development as a cell death imaging agent in living subjects. |
|---|---|
| AbstractList | Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich membranes and act as cell death molecular imaging agents. However, there is a need to improve in vivo imaging performance by selectively increasing target affinity and decreasing off-target accumulation. This present study compared the cell death targeting ability of two new deep-red fluorescent probes containing phenoxide-bridged Zn2BDPA complexes. One probe was a bivalent version of the other and associated more strongly with PS-rich liposome membranes. However, the bivalent probe exhibited self-quenching on the membrane surface, so the monovalent version produced brighter micrographs of dead and dying cells in cell culture and also better fluorescence imaging contrast in two living animal models of cell death (rat implanted tumor with necrotic core and mouse thymus atrophy). An 111In-labeled radiotracer version of the monovalent probe also exhibited selective cell death targeting ability in the mouse thymus atrophy model, with relatively high amounts detected in dead and dying tissue and low off-target accumulation in nonclearance organs. The in vivo biodistribution profile is the most favorable yet reported for a Zn2BDPA complex; thus, the monovalent phenoxide-bridged Zn2BDPA scaffold is a promising candidate for further development as a cell death imaging agent in living subjects. Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich membranes and act as cell death molecular imaging agents. However, there is a need to improve in vivo imaging performance by selectively increasing target affinity and decreasing off-target accumulation. This present study compared the cell death targeting ability of two new deep-red fluorescent probes containing phenoxide-bridged Zn2BDPA complexes. One probe was a bivalent version of the other and associated more strongly with PS-rich liposome membranes. However, the bivalent probe exhibited self-quenching on the membrane surface, so the monovalent version produced brighter micrographs of dead and dying cells in cell culture and also better fluorescence imaging contrast in two living animal models of cell death (rat implanted tumor with necrotic core and mouse thymus atrophy). An (111)In-labeled radiotracer version of the monovalent probe also exhibited selective cell death targeting ability in the mouse thymus atrophy model, with relatively high amounts detected in dead and dying tissue and low off-target accumulation in nonclearance organs. The in vivo biodistribution profile is the most favorable yet reported for a Zn2BDPA complex; thus, the monovalent phenoxide-bridged Zn2BDPA scaffold is a promising candidate for further development as a cell death imaging agent in living subjects. Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich membranes and act as cell death molecular imaging agents. However, there is a need to improve in vivo imaging performance by selectively increasing target affinity and decreasing off-target accumulation. This present study compared the cell death targeting ability of two new deep-red fluorescent probes containing phenoxide-bridged Zn2BDPA complexes. One probe was a bivalent version of the other and associated more strongly with PS-rich liposome membranes. However, the bivalent probe exhibited self-quenching on the membrane surface, so the monovalent version produced brighter micrographs of dead and dying cells in cell culture and also better fluorescence imaging contrast in two living animal models of cell death (rat implanted tumor with necrotic core and mouse thymus atrophy). An (111)In-labeled radiotracer version of the monovalent probe also exhibited selective cell death targeting ability in the mouse thymus atrophy model, with relatively high amounts detected in dead and dying tissue and low off-target accumulation in nonclearance organs. The in vivo biodistribution profile is the most favorable yet reported for a Zn2BDPA complex; thus, the monovalent phenoxide-bridged Zn2BDPA scaffold is a promising candidate for further development as a cell death imaging agent in living subjects.Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn2BDPA) coordination complexes are known to selectively recognize PS-rich membranes and act as cell death molecular imaging agents. However, there is a need to improve in vivo imaging performance by selectively increasing target affinity and decreasing off-target accumulation. This present study compared the cell death targeting ability of two new deep-red fluorescent probes containing phenoxide-bridged Zn2BDPA complexes. One probe was a bivalent version of the other and associated more strongly with PS-rich liposome membranes. However, the bivalent probe exhibited self-quenching on the membrane surface, so the monovalent version produced brighter micrographs of dead and dying cells in cell culture and also better fluorescence imaging contrast in two living animal models of cell death (rat implanted tumor with necrotic core and mouse thymus atrophy). An (111)In-labeled radiotracer version of the monovalent probe also exhibited selective cell death targeting ability in the mouse thymus atrophy model, with relatively high amounts detected in dead and dying tissue and low off-target accumulation in nonclearance organs. The in vivo biodistribution profile is the most favorable yet reported for a Zn2BDPA complex; thus, the monovalent phenoxide-bridged Zn2BDPA scaffold is a promising candidate for further development as a cell death imaging agent in living subjects. Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn 2 BDPA) coordination complexes are known to selectively recognize PS-rich membranes and act as cell death molecular imaging agents. However, there is a need to improve in vivo imaging performance by selectively increasing target affinity and decreasing off-target accumulation. This present study compared the cell death targeting ability of two new deep-red fluorescent probes containing phenoxide-bridged Zn 2 BDPA complexes. One probe was a bivalent version of the other, and associated more strongly with PS-rich liposome membranes. But, the bivalent probe exhibited self-quenching on the membrane surface, so the monovalent version produced brighter micrographs of dead and dying cells in cell culture and also better fluorescence imaging contrast in two living animal models of cell death (rat implanted tumor with necrotic core and mouse thymus atrophy). An 111 In-labelled radiotracer version of the monovalent probe also exhibited selective cell death targeting ability in the mouse thymus atrophy model, with relatively high amounts in dead and dying tissue and low off-target accumulation in non-clearance organs. The in vivo biodistribution profile is the most favorable yet reported for a Zn 2 BDPA complex and thus the monovalent phenoxide-bridged Zn 2 BDPA scaffold is a promising candidate for further development as a cell death imaging agent in living subjects. Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death. One of the best known biomarkers of cell death is exposure of the anionic phospholipid phosphatidylserine (PS) on the surface of dead and dying cells. Synthetic zinc(II)-bis(dipicolylamine) (Zn(2)BDPA) coordination complexes are known to selectively recognize PS-rich membranes and act as cell death molecular imaging agents. However, there is a need to improve in vivo imaging performance by selectively increasing target affinity and decreasing off-target accumulation. This present study compared the cell death targeting ability of two new deep-red fluorescent probes containing phenoxide-bridged Zn(2)BDPA complexes. One probe was a bivalent version of the other and associated more strongly with PS-rich liposome membranes. However, the bivalent probe exhibited self quenching on the membrane surface, so the monovalent version produced brighter micrographs of dead and dying cells in cell culture and also better fluorescence imaging contrast in two living animal models of cell death (rat implanted tumor with necrotic core and mouse thymus atrophy). An In-111-labeled radiotracer version of the monovalent probe also exhibited selective cell death targeting ability in the mouse thymus atrophy model, with relatively high amounts detected in dead and dying tissue and low off target accumulation in nonclearance organs. The in vivo biodistribution profile is the most favorable yet reported for a Zn(2)BDPA complex; thus, the monovalent phenoxide-bridged Zn(2)BDPA scaffold is a promising candidate for further development as a cell death imaging agent in living subjects. |
| Author | Clear, Kasey J Rusckowski, Mary Wolter, William R Wang, Yuzhen Harmatys, Kara M Smith, Bradley D Rice, Douglas R Suckow, Mark A |
| AuthorAffiliation | University of Massachusetts Medical School Department of Chemistry and Biochemistry Division of Nuclear Medicine, Department of Radiology Freimann Life Science Center University of Notre Dame |
| AuthorAffiliation_xml | – name: University of Massachusetts Medical School – name: Freimann Life Science Center – name: Division of Nuclear Medicine, Department of Radiology – name: University of Notre Dame – name: Department of Chemistry and Biochemistry – name: Freimann Life Science Center, 400 Galvin Life Science, University of Notre Dame, Notre Dame, Indiana 46556, United States – name: Department of Chemistry and Biochemistry, 236 Nieuwland Science Hall, University of Notre Dame, Notre Dame, Indiana 46556, United States – name: Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, MA, 01655, USA |
| Author_xml | – sequence: 1 givenname: Kasey J surname: Clear fullname: Clear, Kasey J – sequence: 2 givenname: Kara M surname: Harmatys fullname: Harmatys, Kara M – sequence: 3 givenname: Douglas R surname: Rice fullname: Rice, Douglas R – sequence: 4 givenname: William R surname: Wolter fullname: Wolter, William R – sequence: 5 givenname: Mark A surname: Suckow fullname: Suckow, Mark A – sequence: 6 givenname: Yuzhen surname: Wang fullname: Wang, Yuzhen – sequence: 7 givenname: Mary surname: Rusckowski fullname: Rusckowski, Mary – sequence: 8 givenname: Bradley D surname: Smith fullname: Smith, Bradley D email: smith.115@nd.edu |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/26334386$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNkk9v1DAQxS3Uiv6BrwA5boWy2I4TOwcq0dCWlYroAQ5wsRxnvOtVYi92AvTb49Vuq8KlnDySf--Nx_NO0IHzDhB6TfCcYEreKh3nrfXau7VewTAvW4wZ48_QMSkpzpkg9CDVmBU5EZgeoZMY1xjjmgj6HB3RqihYIapj9O12Bc7_th3kF8F2S-iy79bp2WJxll_YOOvsxmrf3_VqsA7OstvgW4iZ8SH75HvQU69CthjU0rpl5k3WQN9nH0CNqxfo0Kg-wsv9eYq-Xl1-aT7mN5-vF837m1wxQse8EJRxw4zmdbt9FKWq5JhwrhUvdWkMNmUrOkV5xVVHC6NZGtGI2kBH6s4Up-h857uZ2gE6DW4MqpebYAcV7qRXVv594-xKLv1PyWrCBa-SwWxvEPyPCeIoBxt1mkM58FOUhFcVrUpMWEJfPe710OT-PxMgdsAvaL2J2oLT8IClBRQcl4JWqSKksaMarXeNn9yYpG_-X5rodztaBx9jACP13i3NaHtJsNwGRaagyEdBkfugJD3_R3_f6WllsVNugbWfgkvbfVL1BzqV2IQ |
| CitedBy_id | crossref_primary_10_3762_bjoc_11_274 crossref_primary_10_1016_j_cclet_2019_07_056 crossref_primary_10_1039_C6CC03669D crossref_primary_10_1002_cmdc_201800252 crossref_primary_10_1016_j_ccr_2020_213550 crossref_primary_10_1016_j_jtha_2024_10_007 crossref_primary_10_1021_acs_bioconjchem_0c00119 crossref_primary_10_1039_C9CC03242H crossref_primary_10_1016_j_saa_2020_118588 crossref_primary_10_1039_c6pp00151c crossref_primary_10_1039_D4TB01945H crossref_primary_10_1021_acs_bioconjchem_7b00012 crossref_primary_10_1002_ange_201601621 crossref_primary_10_1016_j_trac_2020_116092 crossref_primary_10_1021_acs_jmedchem_1c00858 crossref_primary_10_1002_anie_201601621 crossref_primary_10_1039_C9RA05484G crossref_primary_10_1039_C8TB01495G crossref_primary_10_1002_jsde_12155 crossref_primary_10_1016_j_jinorgbio_2022_112065 crossref_primary_10_1186_s12880_017_0200_1 |
| Cites_doi | 10.1021/ja908467y 10.1039/c3ob41677a 10.1186/2191-219X-1-17 10.1039/c3cc43469a 10.1186/2191-219X-1-26 10.1021/ja507790z 10.1021/bc3003309 10.1002/cbic.200700489 10.1074/jbc.M707637200 10.1007/s10495-011-0601-5 10.1177/002215540305101214 10.1002/asia.201201139 10.1111/j.1365-2796.2010.02282.x 10.1007/BF02537051 10.1007/s11307-014-0758-8 10.1016/j.cub.2012.05.052 10.1021/ol0510421 10.1021/ja0618604 10.1021/ja8008924 10.1074/jbc.M110.163527 10.1073/pnas.95.11.6349 10.1002/cbic.200500149 10.1021/mp300720k 10.1016/j.biomaterials.2013.11.052 10.1016/j.tet.2004.08.052 10.1016/j.dyepig.2010.12.008 10.1021/mp900106m 10.1021/bc500003x 10.1021/ja205911n 10.1016/0006-2952(92)90339-K 10.1021/am508838z 10.1021/bc050330e 10.1371/journal.pone.0096749 10.1016/j.ccr.2012.02.017 10.1002/smll.201302920 10.1097/01.LAB.0000078687.21634.69 10.1016/S1388-1981(00)00100-1 10.2310/7290.2007.00037 10.1016/j.bmcl.2012.02.078 10.1007/BF03220017 10.1021/jm101477d 10.1016/j.bmc.2011.04.029 10.1039/b608684e 10.1038/jcbfm.2014.115 10.1021/mp100395u 10.1016/j.tet.2014.07.104 10.1002/cbic.200700627 10.1021/bc200457b 10.2967/jnumed.112.114264 10.1021/ja910703v 10.1007/s10495-013-0852-4 10.1007/s10495-010-0503-y |
| ContentType | Journal Article |
| Copyright | Copyright © 2015 American Chemical Society |
| Copyright_xml | – notice: Copyright © 2015 American Chemical Society |
| DBID | AAYXX CITATION 17B 1KM BLEPL DTL EGQ GYFQL CGR CUY CVF ECM EIF NPM 7X8 5PM |
| DOI | 10.1021/acs.bioconjchem.5b00447 |
| DatabaseName | CrossRef Web of Knowledge Index Chemicus Web of Science Core Collection Science Citation Index Expanded Web of Science Primary (SCIE, SSCI & AHCI) Web of Science - Science Citation Index Expanded - 2016 Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef Web of Science MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic Web of Science |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 1KM name: Index Chemicus url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.IC sourceTypes: Enrichment Source Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry Biology |
| EISSN | 1520-4812 |
| EndPage | 375 |
| ExternalDocumentID | PMC4917876 26334386 000370582600011 10_1021_acs_bioconjchem_5b00447 c384407367 |
| Genre | Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GrantInformation_xml | – fundername: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) grantid: T32GM075762 – fundername: NIH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA grantid: RO1GM059078; T32GM075762 – fundername: GAANN; US Department of Education – fundername: NIGMS NIH HHS grantid: R01 GM059078 – fundername: NIGMS NIH HHS grantid: T32GM075762 – fundername: NIGMS NIH HHS grantid: R01GM059078 – fundername: NIGMS NIH HHS grantid: T32 GM075762 |
| GroupedDBID | - 23N 53G 55A 5GY 7~N AABXI ABMVS ABUCX ACGFS ACIWK ACJ ACPRK ACS AEESW AENEX AFEFF AFRAH ALMA_UNASSIGNED_HOLDINGS AQSVZ CS3 DU5 EBS ED ED~ EJD F5P GNL IH9 JG JG~ LG6 P2P PQEST PQQKQ ROL TN5 TWZ UI2 VF5 VG9 W1F X XKZ YZZ --- -~X 4.4 5VS AAYXX ABBLG ABJNI ABLBI ABQRX ADHLV AGXLV AHGAQ BAANH CITATION CUPRZ GGK 17B 1KM BLEPL DTL GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED GROUPED_WOS_WEB_OF_SCIENCE CGR CUY CVF ECM EIF NPM 7X8 5PM |
| ID | FETCH-LOGICAL-a412t-38247f4fc79b334322a570177ca75c5ff0f5b8da2767ad23fc4152f89fed19df3 |
| IEDL.DBID | ACS |
| ISICitedReferencesCount | 21 |
| ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=000370582600011 |
| ISSN | 1043-1802 1520-4812 |
| IngestDate | Thu Aug 21 14:26:16 EDT 2025 Thu Jul 10 19:23:20 EDT 2025 Thu Jan 02 22:19:38 EST 2025 Wed Jul 09 09:10:54 EDT 2025 Sat Sep 06 05:26:12 EDT 2025 Tue Jul 01 02:22:58 EDT 2025 Thu Apr 24 23:00:26 EDT 2025 Thu Aug 27 13:44:09 EDT 2020 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | BIOMARKERS RNA PHOSPHATIDYLSERINE EXPRESSION APOPTOTIC CELLS ANNEXIN-V SURFACE COORDINATION-COMPLEXES FLUORESCENCE DETECTION |
| Language | English |
| LinkModel | DirectLink |
| LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
| MergedId | FETCHMERGED-LOGICAL-a412t-38247f4fc79b334322a570177ca75c5ff0f5b8da2767ad23fc4152f89fed19df3 |
| Notes | NIH RePORTER ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0001-8628-681X 0000-0001-7317-697X |
| PMID | 26334386 |
| PQID | 1766265014 |
| PQPubID | 23479 |
| PageCount | 13 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_4917876 acs_journals_10_1021_acs_bioconjchem_5b00447 pubmed_primary_26334386 webofscience_primary_000370582600011 webofscience_primary_000370582600011CitationCount crossref_primary_10_1021_acs_bioconjchem_5b00447 crossref_citationtrail_10_1021_acs_bioconjchem_5b00447 proquest_miscellaneous_1766265014 |
| ProviderPackageCode | JG~ 55A AABXI GNL VF5 XKZ 7~N ACJ VG9 W1F ACS AEESW AFEFF ABMVS ABUCX IH9 AQSVZ ED~ UI2 CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-02-17 |
| PublicationDateYYYYMMDD | 2016-02-17 |
| PublicationDate_xml | – month: 02 year: 2016 text: 2016-02-17 day: 17 |
| PublicationDecade | 2010 |
| PublicationPlace | WASHINGTON |
| PublicationPlace_xml | – name: WASHINGTON – name: United States |
| PublicationTitle | Bioconjugate chemistry |
| PublicationTitleAbbrev | BIOCONJUGATE CHEM |
| PublicationTitleAlternate | Bioconjugate Chem |
| PublicationYear | 2016 |
| Publisher | American Chemical Society Amer Chemical Soc |
| Publisher_xml | – name: American Chemical Society – name: Amer Chemical Soc |
| References | ref9/cit9 ref45/cit45 ref3/cit3 ref27/cit27 ref16/cit16 ref52/cit52 ref23/cit23 ref8/cit8 ref31/cit31 ref2/cit2 ref34/cit34 ref37/cit37 ref20/cit20 ref48/cit48 ref17/cit17 ref10/cit10 ref35/cit35 ref19/cit19 ref21/cit21 ref42/cit42 ref46/cit46 ref49/cit49 ref13/cit13 ref24/cit24 ref38/cit38 ref50/cit50 ref6/cit6 ref36/cit36 ref18/cit18 Shao R. (ref14/cit14) 2007; 6 ref11/cit11 ref25/cit25 ref29/cit29 ref32/cit32 ref39/cit39 ref5/cit5 ref51/cit51 ref43/cit43 ref28/cit28 ref40/cit40 ref26/cit26 ref12/cit12 ref15/cit15 ref41/cit41 ref22/cit22 ref33/cit33 ref4/cit4 ref30/cit30 ref47/cit47 ref1/cit1 ref44/cit44 ref7/cit7 Mapes, J (WOS:000306823700015) 2012; 22 Blankenberg, FG (WOS:000073852600089) 1998; 95 Wang, HL (WOS:000321153300010) 2013; 18 Shao, R (WOS:000251569400005) 2007; 6 Neves, AA (WOS:000329183600007) 2014; 55 Smith, BA (WOS:000326128700003) 2013; 10 Rice, DR (WOS:000351092900007) 2015; 17 Lederle, W (WOS:000209435600026) 2011; 1 Nonaka, H (WOS:000279745700028) 2010; 132 STERINSPEZIALE, N (WOS:A1992GZ38100002) 1992; 27 Smith, BA (WOS:000309855000001) 2012; 23 Li, J (WOS:000333708900018) 2014; 10 Ojida, A (WOS:000239618700028) 2006; 128 Smith, BA (WOS:000275084400032) 2010; 132 Ungethum, L (WOS:000338029800121) 2014; 9 Herce, HD (WOS:000346682600024) 2014; 136 Plaunt, AJ (WOS:000334657500012) 2014; 25 White, AG (WOS:000302768200040) 2012; 22 Zille, M (WOS:000341342800018) 2014; 34 Belhocine, TZ (WOS:000209435600017) 2011; 1 Song, GF (WOS:000331502300003) 2014; 35 Cho, YS (WOS:000316634200012) 2013; 8 Zheng, H (WOS:000295911500016) 2011; 133 Hosseini, AS (WOS:000342711300005) 2014; 70 Smith, BA (WOS:000290803400007) 2011; 16 Lakshmi, C (WOS:000225053700030) 2004; 60 Zhivotovsky, B (WOS:000283374600001) 2010; 268 Hanshaw, RG (WOS:000233916600016) 2005; 6 Shao, FW (WOS:000288737800005) 2011; 90 Matsuda, R (WOS:000166767800002) 2001; 200 Galande, AK (WOS:000236226200001) 2006; 17 Jiang, H (WOS:000230213100053) 2005; 7 DiVittorio, KM (WOS:000252880000016) 2008; 9 Oltmanns, D (WOS:000298222300028) 2011; 22 Wyffels, L (WOS:000290955400016) 2011; 19 Yu, A (WOS:000089680200018) 2000; 1487 Bamri-Ezzine, S (WOS:000184392200015) 2003; 83 Smith, BA (WOS:000289008600027) 2011; 8 Xiong, CY (WOS:000288400700023) 2011; 54 Jeppesen, B (WOS:000253779500019) 2008; 283 Berlier, JE (WOS:000186878400014) 2003; 51 Ungethum, L (WOS:000286191500031) 2011; 286 Nakasone, ES (WOS:000303187400007) 2012; 21 Cooley, CM (WOS:000326310800016) 2013; 11 Kohira, T (WOS:000254882500007) 2008; 9 Stevens, N (WOS:000256550600008) 2008; 130 Burtea, C (WOS:000272461300024) 2009; 6 Hu, QL (WOS:000353005300054) 2015; 7 Honda, K (WOS:000240775200020) 2006 SUN, XM (WOS:A1992KC34100007) 1992; 44 Zhang, T (WOS:000321956400022) 2013; 49 Schutters, K (WOS:000281402300006) 2010; 15 24984896 - J Cereb Blood Flow Metab. 2014 Sep;34(9):null 11018481 - Biochim Biophys Acta. 2000 Sep 27;1487(2-3):296-308 20568758 - J Am Chem Soc. 2010 Jul 14;132(27):9301-9 25115869 - Mol Imaging Biol. 2015 Apr;17 (2):204-13 23341205 - Chem Asian J. 2013 Apr;8(4):755-9 21499791 - Apoptosis. 2011 Jul;16(7):722-31 1472078 - Biochem Pharmacol. 1992 Dec 1;44(11):2131-7 9600968 - Proc Natl Acad Sci U S A. 1998 May 26;95(11):6349-54 21348464 - J Med Chem. 2011 Mar 24;54(6):1825-35 22214377 - EJNMMI Res. 2011 Nov 17;1(1):26 20014845 - J Am Chem Soc. 2010 Jan 13;132(1):67-9 22040278 - Bioconjug Chem. 2011 Dec 21;22(12 ):2611-24 18174168 - J Biol Chem. 2008 Mar 7;283(10):6126-35 20964732 - J Intern Med. 2010 Nov;268(5):395-409 23613106 - Apoptosis. 2013 Aug;18(8):1017-27 15987193 - Org Lett. 2005 Jul 7;7(14):3013-6 25405895 - J Am Chem Soc. 2014 Dec 17;136(50):17459-67 22989049 - Bioconjug Chem. 2012 Oct 17;23(10):1989-2006 22424976 - Bioorg Med Chem Lett. 2012 Apr 15;22(8):2833-6 23915311 - Mol Pharm. 2013 Sep 3;10(9):3296-303 21078669 - J Biol Chem. 2011 Jan 21;286(3):1903-10 22214386 - EJNMMI Res. 2011 Aug 22;1(1):17 19743879 - Mol Pharm. 2009 Nov-Dec;6(6):1903-19 16895410 - J Am Chem Soc. 2006 Aug 16;128(32):10452-9 21899316 - J Am Chem Soc. 2011 Oct 5;133(39):15280-3 16276499 - Chembiochem. 2005 Dec;6(12):2214-20 14623938 - J Histochem Cytochem. 2003 Dec;51(12):1699-712 24801051 - PLoS One. 2014 May 06;9(5):e96749 1608296 - Lipids. 1992 Jan;27(1):10-4 24065122 - Org Biomol Chem. 2013 Nov 14;11(42):7387-92 24385310 - J Nucl Med. 2014 Jan;55(1):1-4 20440562 - Apoptosis. 2010 Sep;15(9):1072-82 23846331 - Chem Commun (Camb). 2013 Aug 21;49(65):7252-4 21323375 - Mol Pharm. 2011 Apr 4;8(2):583-90 18076009 - Chembiochem. 2008 Jan 25;9(2):286-93 22516258 - Cancer Cell. 2012 Apr 17;21(4):488-503 18053412 - Mol Imaging. 2007 Nov-Dec;6(6):417-26 21570306 - Bioorg Med Chem. 2011 Jun 1;19(11):3425-33 11271515 - Res Exp Med (Berl). 2001 Jan;200(2):77-92 24332461 - Biomaterials. 2014 Feb;35(7):2103-12 24130101 - Small. 2014 Apr 9;10(7):1351-60 25671791 - ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4875-82 24575875 - Bioconjug Chem. 2014 Apr 16;25(4):724-37 21475610 - Dyes Pigm. 2011 Apr 1;90(2):119-122 12861046 - Lab Invest. 2003 Jul;83(7):1069-80 25419010 - Tetrahedron. 2014 Oct 21;70(42):7632-7638 18253939 - Chembiochem. 2008 Mar 25;9(5):698-701 17003887 - Chem Commun (Camb). 2006 Oct 14;(38):4024-6 16536452 - Bioconjug Chem. 2006 Mar-Apr;17(2):255-7 18489094 - J Am Chem Soc. 2008 Jun 11;130(23):7182-3 22727702 - Curr Biol. 2012 Jul 24;22(14):1267-75 |
| References_xml | – ident: ref37/cit37 doi: 10.1021/ja908467y – ident: ref16/cit16 doi: 10.1039/c3ob41677a – ident: ref5/cit5 doi: 10.1186/2191-219X-1-17 – ident: ref18/cit18 doi: 10.1039/c3cc43469a – ident: ref9/cit9 doi: 10.1186/2191-219X-1-26 – ident: ref42/cit42 doi: 10.1021/ja507790z – ident: ref2/cit2 doi: 10.1021/bc3003309 – ident: ref28/cit28 doi: 10.1002/cbic.200700489 – ident: ref38/cit38 doi: 10.1074/jbc.M707637200 – ident: ref21/cit21 doi: 10.1007/s10495-011-0601-5 – ident: ref35/cit35 doi: 10.1177/002215540305101214 – ident: ref22/cit22 doi: 10.1002/asia.201201139 – ident: ref1/cit1 doi: 10.1111/j.1365-2796.2010.02282.x – ident: ref48/cit48 doi: 10.1007/BF02537051 – ident: ref49/cit49 doi: 10.1007/s11307-014-0758-8 – ident: ref6/cit6 doi: 10.1016/j.cub.2012.05.052 – ident: ref27/cit27 doi: 10.1021/ol0510421 – ident: ref30/cit30 doi: 10.1021/ja0618604 – ident: ref40/cit40 doi: 10.1021/ja8008924 – ident: ref8/cit8 doi: 10.1074/jbc.M110.163527 – ident: ref44/cit44 doi: 10.1073/pnas.95.11.6349 – ident: ref24/cit24 doi: 10.1002/cbic.200500149 – ident: ref26/cit26 doi: 10.1021/mp300720k – ident: ref41/cit41 doi: 10.1016/j.biomaterials.2013.11.052 – ident: ref23/cit23 doi: 10.1016/j.tet.2004.08.052 – ident: ref33/cit33 doi: 10.1016/j.dyepig.2010.12.008 – ident: ref10/cit10 doi: 10.1021/mp900106m – ident: ref25/cit25 doi: 10.1021/bc500003x – ident: ref13/cit13 doi: 10.1021/ja205911n – ident: ref43/cit43 doi: 10.1016/0006-2952(92)90339-K – ident: ref19/cit19 doi: 10.1021/am508838z – ident: ref34/cit34 doi: 10.1021/bc050330e – ident: ref7/cit7 doi: 10.1371/journal.pone.0096749 – ident: ref52/cit52 doi: 10.1016/j.ccr.2012.02.017 – ident: ref17/cit17 doi: 10.1002/smll.201302920 – ident: ref46/cit46 doi: 10.1097/01.LAB.0000078687.21634.69 – ident: ref39/cit39 doi: 10.1016/S1388-1981(00)00100-1 – volume: 6 start-page: 417 year: 2007 ident: ref14/cit14 publication-title: Mol. Imaging doi: 10.2310/7290.2007.00037 – ident: ref32/cit32 doi: 10.1016/j.bmcl.2012.02.078 – ident: ref47/cit47 doi: 10.1007/BF03220017 – ident: ref11/cit11 doi: 10.1021/jm101477d – ident: ref51/cit51 doi: 10.1016/j.bmc.2011.04.029 – ident: ref31/cit31 doi: 10.1039/b608684e – ident: ref45/cit45 doi: 10.1038/jcbfm.2014.115 – ident: ref20/cit20 doi: 10.1021/mp100395u – ident: ref12/cit12 doi: 10.1016/j.tet.2014.07.104 – ident: ref36/cit36 doi: 10.1002/cbic.200700627 – ident: ref15/cit15 doi: 10.1021/bc200457b – ident: ref3/cit3 doi: 10.2967/jnumed.112.114264 – ident: ref29/cit29 doi: 10.1021/ja910703v – ident: ref50/cit50 doi: 10.1007/s10495-013-0852-4 – ident: ref4/cit4 doi: 10.1007/s10495-010-0503-y – volume: 133 start-page: 15280 year: 2011 ident: WOS:000295911500016 article-title: Cofactor-Free Detection of Phosphatidylserine with Cyclic Peptides Mimicking Lactadherin publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja205911n – volume: 1487 start-page: 296 year: 2000 ident: WOS:000089680200018 article-title: Preferential externalization of newly synthesized phosphatidylserine in apoptotic U937 cells is dependent on caspase-mediated pathways publication-title: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS – volume: 22 start-page: 2833 year: 2012 ident: WOS:000302768200040 article-title: Deep-red fluorescent imaging probe for bacteria publication-title: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS doi: 10.1016/j.bmcl.2012.02.078 – volume: 10 start-page: 3296 year: 2013 ident: WOS:000326128700003 article-title: Enhanced Cell Death Imaging Using Multivalent Zinc(II)-bis(dipicolylamine) Fluorescent Probes publication-title: MOLECULAR PHARMACEUTICS doi: 10.1021/mp300720k – volume: 6 start-page: 1903 year: 2009 ident: WOS:000272461300024 article-title: Peptidic Targeting of Phosphatidylserine for the MRI Detection of Apoptosis in Atherosclerotic Plaques publication-title: MOLECULAR PHARMACEUTICS doi: 10.1021/mp900106m – volume: 1 start-page: ARTN 26 year: 2011 ident: WOS:000209435600026 article-title: Failure of annexin-based apoptosis imaging in the assessment of antiangiogenic therapy effects publication-title: EJNMMI RESEARCH doi: 10.1186/2191-219X-1-26 – volume: 286 start-page: 1903 year: 2011 ident: WOS:000286191500031 article-title: Engineered Annexin A5 Variants Have Impaired Cell Entry for Molecular Imaging of Apoptosis Using Pretargeting Strategies publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY doi: 10.1074/jbc.M110.163527 – volume: 7 start-page: 3013 year: 2005 ident: WOS:000230213100053 article-title: Anion-mediated phase transfer of zinc(II)-coordinated tyrosine derivatives publication-title: ORGANIC LETTERS doi: 10.1021/ol0510421 – volume: 8 start-page: 583 year: 2011 ident: WOS:000289008600027 article-title: In Vivo Optical Imaging of Acute Cell Death Using a Near-Infrared Fluorescent Zinc-Dipicolylamine Probe publication-title: MOLECULAR PHARMACEUTICS doi: 10.1021/mp100395u – volume: 7 start-page: 4875 year: 2015 ident: WOS:000353005300054 article-title: A Cell Apoptosis Probe Based on Fluorogen with Aggregation Induced Emission Characteristics publication-title: ACS APPLIED MATERIALS & INTERFACES doi: 10.1021/am508838z – volume: 19 start-page: 3425 year: 2011 ident: WOS:000290955400016 article-title: Synthesis and preliminary evaluation of radiolabeled bis(zinc(II)-dipicolylamine) coordination complexes as cell death imaging agents publication-title: BIOORGANIC & MEDICINAL CHEMISTRY doi: 10.1016/j.bmc.2011.04.029 – volume: 1 start-page: ARTN 17 year: 2011 ident: WOS:000209435600017 article-title: Transbilayer phospholipids molecular imaging publication-title: EJNMMI RESEARCH doi: 10.1186/2191-219X-1-17 – volume: 51 start-page: 1699 year: 2003 ident: WOS:000186878400014 article-title: Quantitative comparison of long-wavelength Alexa Fluor dyes to Cy dyes: Fluorescence of the dyes and their bioconjugates publication-title: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY – volume: 70 start-page: 7632 year: 2014 ident: WOS:000342711300005 article-title: Understanding lipid recognition by protein-mimicking cyclic peptides publication-title: TETRAHEDRON doi: 10.1016/j.tet.2014.07.104 – volume: 268 start-page: 395 year: 2010 ident: WOS:000283374600001 article-title: Cell cycle and cell death in disease: past, present and future publication-title: JOURNAL OF INTERNAL MEDICINE doi: 10.1111/j.1365-2796.2010.02282.x – volume: 21 start-page: 488 year: 2012 ident: WOS:000303187400007 article-title: Imaging Tumor-Stroma Interactions during Chemotherapy Reveals Contributions of the Microenvironment to Resistance publication-title: CANCER CELL doi: 10.1016/j.ccr.2012.02.017 – volume: 55 start-page: 1 year: 2014 ident: WOS:000329183600007 article-title: Imaging Cell Death publication-title: JOURNAL OF NUCLEAR MEDICINE doi: 10.2967/jnumed.112.114264 – volume: 23 start-page: 1989 year: 2012 ident: WOS:000309855000001 article-title: Biomarkers and Molecular Probes for Cell Death Imaging and Targeted Therapeutics publication-title: BIOCONJUGATE CHEMISTRY doi: 10.1021/bc3003309 – volume: 35 start-page: 2103 year: 2014 ident: WOS:000331502300003 article-title: Low molecular weight fluorescent probes with good photostability for imaging RNA-rich nucleolus and RNA in cytoplasm in living cells publication-title: BIOMATERIALS doi: 10.1016/j.biomaterials.2013.11.052 – volume: 130 start-page: 7182 year: 2008 ident: WOS:000256550600008 article-title: Two color RNA intercalating probe for cell imaging applications publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja8008924 – volume: 22 start-page: 2611 year: 2011 ident: WOS:000298222300028 article-title: Zn(II)-bis(cyclen) Complexes and the Imaging of Apoptosis/Necrosis publication-title: BIOCONJUGATE CHEMISTRY doi: 10.1021/bc200457b – volume: 11 start-page: 7387 year: 2013 ident: WOS:000326310800016 article-title: A selective fluorescent chemosensor for phosphoserine publication-title: ORGANIC & BIOMOLECULAR CHEMISTRY doi: 10.1039/c3ob41677a – volume: 25 start-page: 724 year: 2014 ident: WOS:000334657500012 article-title: Library Synthesis, Screening, and Discovery of Modified Zinc(II)-Bis(dipicolylamine) Probe for Enhanced Molecular Imaging of Cell Death publication-title: BIOCONJUGATE CHEMISTRY doi: 10.1021/bc500003x – volume: 54 start-page: 1825 year: 2011 ident: WOS:000288400700023 article-title: Peptide-Based Imaging Agents Targeting Phosphatidylserine for the Detection of Apoptosis publication-title: JOURNAL OF MEDICINAL CHEMISTRY doi: 10.1021/jm101477d – volume: 34 start-page: 1568 year: 2014 ident: WOS:000341342800018 article-title: A dual-labeled Annexin A5 is not suited for SPECT imaging of brain cell death in experimental murine stroke publication-title: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM doi: 10.1038/jcbfm.2014.115 – volume: 9 start-page: 286 year: 2008 ident: WOS:000252880000016 article-title: Zinc(II) coordination complexes as membrane-active fluorescent probes and antibiotics publication-title: CHEMBIOCHEM doi: 10.1002/cbic.200700489 – volume: 128 start-page: 10452 year: 2006 ident: WOS:000239618700028 article-title: Oligo-Asp Tag/Zn(II) complex probe as a new pair for labeling and fluorescence imaging of proteins publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja0618604 – volume: 49 start-page: 7252 year: 2013 ident: WOS:000321956400022 article-title: Porphyrin-based ytterbium complexes targeting anionic phospholipid membranes as selective biomarkers for cancer cell imaging publication-title: CHEMICAL COMMUNICATIONS doi: 10.1039/c3cc43469a – volume: 132 start-page: 9301 year: 2010 ident: WOS:000279745700028 article-title: Selective Covalent Labeling of Tag-Fused GPCR Proteins on Live Cell Surface with a Synthetic Probe for Their Functional Analysis publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja910703v – volume: 83 start-page: 1069 year: 2003 ident: WOS:000184392200015 article-title: Apoptosis of tubular epithelial cells in glycogen nephrosis during diabetes publication-title: LABORATORY INVESTIGATION doi: 10.1097/01.LAB.0000078687.21634.69 – volume: 17 start-page: 204 year: 2015 ident: WOS:000351092900007 article-title: Evaluation of [In-111]-Labeled Zinc-Dipicolylamine Tracers for SPECT Imaging of Bacterial Infection publication-title: MOLECULAR IMAGING AND BIOLOGY doi: 10.1007/s11307-014-0758-8 – volume: 18 start-page: 1017 year: 2013 ident: WOS:000321153300010 article-title: Noninvasive positron emission tomography imaging of cell death using a novel small-molecule probe, F-18 labeled bis(zinc(II)-dipicolylamine) complex publication-title: APOPTOSIS doi: 10.1007/s10495-013-0852-4 – volume: 8 start-page: 755 year: 2013 ident: WOS:000316634200012 article-title: Turn-On Fluorescence Detection of Apoptotic Cells Using a Zinc(II)-Dipicolylamine-Functionalized Poly(diacetylene) Liposome publication-title: CHEMISTRY-AN ASIAN JOURNAL doi: 10.1002/asia.201201139 – volume: 17 start-page: 255 year: 2006 ident: WOS:000236226200001 article-title: Fluorescence probe with a pH-sensitive trigger publication-title: BIOCONJUGATE CHEMISTRY doi: 10.1021/bc050330e – volume: 132 start-page: 67 year: 2010 ident: WOS:000275084400032 article-title: Optical Imaging of Mammary and Prostate Tumors in Living Animals using a Synthetic Near Infrared Zinc(II)-Dipicolylamine Probe for Anionic Cell Surfaces publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja908467y – volume: 6 start-page: 2214 year: 2005 ident: WOS:000233916600016 article-title: Fluorescent detection of apoptotic cells by using zinc coordination complexes with a selective affinity for membrane surfaces enriched with phosphatidylserine publication-title: CHEMBIOCHEM doi: 10.1002/cbic.200500149 – volume: 60 start-page: 11307 year: 2004 ident: WOS:000225053700030 article-title: Fluorophore-linked zinc(II)dipicolylamine coordination complexes as sensors for phosphatidylserine-containing membranes publication-title: TETRAHEDRON doi: 10.1016/j.tet.2004.08.052 – volume: 22 start-page: 1267 year: 2012 ident: WOS:000306823700015 article-title: CED-1, CED-7, and TTR-52 Regulate Surface Phosphatidylserine Expression on Apoptotic and Phagocytic Cells publication-title: CURRENT BIOLOGY doi: 10.1016/j.cub.2012.05.052 – volume: 16 start-page: 722 year: 2011 ident: WOS:000290803400007 article-title: In vivo targeting of cell death using a synthetic fluorescent molecular probe publication-title: APOPTOSIS doi: 10.1007/s10495-011-0601-5 – start-page: 4024 year: 2006 ident: WOS:000240775200020 article-title: Ratiometric fluorescence detection of a tag fused protein using the dual-emission artificial molecular probe publication-title: CHEMICAL COMMUNICATIONS doi: 10.1039/b608684e – volume: 283 start-page: 6126 year: 2008 ident: WOS:000253779500019 article-title: Entropic and enthalpic contributions to annexin V-membrane binding - A comprehensive quantitative model publication-title: JOURNAL OF BIOLOGICAL CHEMISTRY doi: 10.1074/jbc.M707637200 – volume: 95 start-page: 6349 year: 1998 ident: WOS:000073852600089 article-title: In vivo detection and imaging of phosphatidylserine expression during programmed cell death publication-title: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA – volume: 136 start-page: 17459 year: 2014 ident: WOS:000346682600024 article-title: Fundamental Molecular Mechanism for the Cellular Uptake of Guanidinium-Rich Molecules publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY doi: 10.1021/ja507790z – volume: 10 start-page: 1351 year: 2014 ident: WOS:000333708900018 article-title: A Difunctional Squarylium Indocyanine Dye Distinguishes Dead Cells through Diverse Staining of the Cell Nuclei/Membranes publication-title: SMALL doi: 10.1002/smll.201302920 – volume: 90 start-page: 119 year: 2011 ident: WOS:000288737800005 article-title: Facile synthesis of monofunctional pentamethine carbocyanine fluorophores publication-title: DYES AND PIGMENTS doi: 10.1016/j.dyepig.2010.12.008 – volume: 6 start-page: 417 year: 2007 ident: WOS:000251569400005 article-title: Targeting phosphatidylserine on apoptotic cells with phages and peptides selected from a bacteriophage display library publication-title: MOLECULAR IMAGING doi: 10.2310/7290.2007.00037 – volume: 15 start-page: 1072 year: 2010 ident: WOS:000281402300006 article-title: Phosphatidylserine targeting for diagnosis and treatment of human diseases publication-title: APOPTOSIS doi: 10.1007/s10495-010-0503-y – volume: 200 start-page: 77 year: 2001 ident: WOS:000166767800002 article-title: Localization of annexin V in rat normal kidney and experimental glomerulonephritis publication-title: RESEARCH IN EXPERIMENTAL MEDICINE – volume: 9 start-page: ARTN e96749 year: 2014 ident: WOS:000338029800121 article-title: Molecular Imaging of Cell Death in Tumors. Increasing Annexin A5 Size Reduces Contribution of Phosphatidylserine-Targeting Function to Tumor Uptake publication-title: PLOS ONE doi: 10.1371/journal.pone.0096749 – volume: 9 start-page: 698 year: 2008 ident: WOS:000254882500007 article-title: Artificial receptors designed for intracellular delivery of anionic phosphate derivatives publication-title: CHEMBIOCHEM doi: 10.1002/cbic.200700627 – volume: 44 start-page: 2131 year: 1992 ident: WOS:A1992KC34100007 article-title: CHARACTERIZATION OF APOPTOSIS IN THYMOCYTES ISOLATED FROM DEXAMETHASONE-TREATED RATS publication-title: BIOCHEMICAL PHARMACOLOGY – volume: 27 start-page: 10 year: 1992 ident: WOS:A1992GZ38100002 article-title: COMPARTMENTAL STUDY OF RAT RENAL PHOSPHOLIPID-METABOLISM publication-title: LIPIDS – reference: 24801051 - PLoS One. 2014 May 06;9(5):e96749 – reference: 22040278 - Bioconjug Chem. 2011 Dec 21;22(12 ):2611-24 – reference: 21570306 - Bioorg Med Chem. 2011 Jun 1;19(11):3425-33 – reference: 24575875 - Bioconjug Chem. 2014 Apr 16;25(4):724-37 – reference: 25671791 - ACS Appl Mater Interfaces. 2015 Mar 4;7(8):4875-82 – reference: 24065122 - Org Biomol Chem. 2013 Nov 14;11(42):7387-92 – reference: 18174168 - J Biol Chem. 2008 Mar 7;283(10):6126-35 – reference: 22424976 - Bioorg Med Chem Lett. 2012 Apr 15;22(8):2833-6 – reference: 11018481 - Biochim Biophys Acta. 2000 Sep 27;1487(2-3):296-308 – reference: 19743879 - Mol Pharm. 2009 Nov-Dec;6(6):1903-19 – reference: 21348464 - J Med Chem. 2011 Mar 24;54(6):1825-35 – reference: 23846331 - Chem Commun (Camb). 2013 Aug 21;49(65):7252-4 – reference: 22516258 - Cancer Cell. 2012 Apr 17;21(4):488-503 – reference: 16536452 - Bioconjug Chem. 2006 Mar-Apr;17(2):255-7 – reference: 22214377 - EJNMMI Res. 2011 Nov 17;1(1):26 – reference: 25115869 - Mol Imaging Biol. 2015 Apr;17 (2):204-13 – reference: 11271515 - Res Exp Med (Berl). 2001 Jan;200(2):77-92 – reference: 21078669 - J Biol Chem. 2011 Jan 21;286(3):1903-10 – reference: 12861046 - Lab Invest. 2003 Jul;83(7):1069-80 – reference: 25419010 - Tetrahedron. 2014 Oct 21;70(42):7632-7638 – reference: 1472078 - Biochem Pharmacol. 1992 Dec 1;44(11):2131-7 – reference: 15987193 - Org Lett. 2005 Jul 7;7(14):3013-6 – reference: 18489094 - J Am Chem Soc. 2008 Jun 11;130(23):7182-3 – reference: 20964732 - J Intern Med. 2010 Nov;268(5):395-409 – reference: 23341205 - Chem Asian J. 2013 Apr;8(4):755-9 – reference: 24984896 - J Cereb Blood Flow Metab. 2014 Sep;34(9):null – reference: 23915311 - Mol Pharm. 2013 Sep 3;10(9):3296-303 – reference: 21323375 - Mol Pharm. 2011 Apr 4;8(2):583-90 – reference: 1608296 - Lipids. 1992 Jan;27(1):10-4 – reference: 22214386 - EJNMMI Res. 2011 Aug 22;1(1):17 – reference: 18053412 - Mol Imaging. 2007 Nov-Dec;6(6):417-26 – reference: 16276499 - Chembiochem. 2005 Dec;6(12):2214-20 – reference: 25405895 - J Am Chem Soc. 2014 Dec 17;136(50):17459-67 – reference: 9600968 - Proc Natl Acad Sci U S A. 1998 May 26;95(11):6349-54 – reference: 24332461 - Biomaterials. 2014 Feb;35(7):2103-12 – reference: 23613106 - Apoptosis. 2013 Aug;18(8):1017-27 – reference: 20014845 - J Am Chem Soc. 2010 Jan 13;132(1):67-9 – reference: 21899316 - J Am Chem Soc. 2011 Oct 5;133(39):15280-3 – reference: 20440562 - Apoptosis. 2010 Sep;15(9):1072-82 – reference: 21499791 - Apoptosis. 2011 Jul;16(7):722-31 – reference: 20568758 - J Am Chem Soc. 2010 Jul 14;132(27):9301-9 – reference: 18253939 - Chembiochem. 2008 Mar 25;9(5):698-701 – reference: 22727702 - Curr Biol. 2012 Jul 24;22(14):1267-75 – reference: 24130101 - Small. 2014 Apr 9;10(7):1351-60 – reference: 24385310 - J Nucl Med. 2014 Jan;55(1):1-4 – reference: 17003887 - Chem Commun (Camb). 2006 Oct 14;(38):4024-6 – reference: 14623938 - J Histochem Cytochem. 2003 Dec;51(12):1699-712 – reference: 16895410 - J Am Chem Soc. 2006 Aug 16;128(32):10452-9 – reference: 18076009 - Chembiochem. 2008 Jan 25;9(2):286-93 – reference: 22989049 - Bioconjug Chem. 2012 Oct 17;23(10):1989-2006 – reference: 21475610 - Dyes Pigm. 2011 Apr 1;90(2):119-122 |
| SSID | ssj0009182 |
| Score | 2.2842963 |
| Snippet | Cell death is involved in many pathological conditions, and there is a need for clinical and preclinical imaging agents that can target and report cell death.... |
| Source | Web of Science |
| SourceID | pubmedcentral proquest pubmed webofscience crossref acs |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 363 |
| SubjectTerms | Animals Atrophy - diagnosis Atrophy - pathology Biochemical Research Methods Biochemistry & Molecular Biology Cell Death Cell Line, Tumor Chemistry Chemistry, Multidisciplinary Chemistry, Organic CHO Cells Cricetulus Female Fluorescent Dyes - chemistry Life Sciences & Biomedicine Male Mice Microscopy, Fluorescence - methods Molecular Imaging - methods Neoplasms - diagnosis Neoplasms - pathology Optical Imaging - methods Organometallic Compounds - chemistry Phosphatidylserines - analysis Physical Sciences Picolinic Acids - chemistry Rats Rats, Wistar Science & Technology Thymus Gland - cytology Thymus Gland - pathology |
| Title | Phenoxide-Bridged Zinc(II)-Bis(dipicolylamine) Probes for Molecular Imaging of Cell Death |
| URI | http://dx.doi.org/10.1021/acs.bioconjchem.5b00447 http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=000370582600011 https://www.ncbi.nlm.nih.gov/pubmed/26334386 https://www.proquest.com/docview/1766265014 https://pubmed.ncbi.nlm.nih.gov/PMC4917876 |
| Volume | 27 |
| WOS | 000370582600011 |
| WOSCitedRecordID | wos000370582600011 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3bbtQwEB2VIgQvXFou4WqkCrUSWWLHjp3HbqDqIhVVQKXSl8hxbDWwm1QkK1G-HjuXpUtBW95W2ThKJieZM5mZMwBbOdbCEGp8bem4T7GI_NjE0g8jaYgkgQmUa3A--BDtH9H3x-x4DfA_MvgEv5GqHmVFZaPDr_YyZiPmgEb5NbhOIgs2x4aST791drHoEpxOeVO44p0XKw7k3JKql93SJa7595LJP9xU65L27sDHobGnq0T5Npo32Uj9vKzzePWrvQu3e4KKdjtE3YM1XW7A5m5pg_PZOXqF2pLR9lv8BtwYD79uJsPguE34cniqy-pHkWt_3LaD5eikKNX2ZLLjj4t6Oy_OHPzOLRYtxd1Bh64jqUaWPaODYVgvmsza8UmoMijR0yl666jqfTjae_c52ff7CQ6-pJg0figI5YYaxeMsdC2sRDJu3wFcSc4UMyYwLBO5JDziMiehUY5PGBEbneM4N-EDWC-rUj8CxGSYC64YUYJSpuPMBooml7E2IVbW4Xjw2tou7Z_AOm2T6wSnbuMFg6a9QT2Ihvudql4N3Q3lmK5eGCwWnnWCIKuXvBwAldpb4TIystTV3J4kj2xA6VK7HjzsALY4KImcxUTkAV-C3mIHJwy-_E9ZnLYC4dTG4NbLebB1EaSLha3oUMCEm01gX-8e4KvslvRWcloJzeP_s_YTuGWJZlvtjvlTWG--z_UzS-aa7Hn7-P4C-PlH8Q |
| linkProvider | American Chemical Society |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3rb9MwED-NITS-8Nh4hNeMNKFNIqVxHnY-toWphXWaxCZtfIkcx9YCbTKRVmL89ZzdJFsHUoFvUWJb8eWS-13u7ncAO5mnuKaBdhXCcTfweOTGOhauHwlNBe3qrjQFzuPDaHgSfDwNT9eAN7UweBMVrlTZIP4Vu4D3zpxL8xKdxK-4m2knNPoWsFtwGyEJNU0beoPPV3S7Hl_EOQ0BJzc5PNsrFjLWSVbL1uk3yPnnzMkb1spapv37cNbuySakfOvMZ2lH_rxB9_g_m34A92q4SnoL_XoIa6rYhK1ega769JK8ITaB1P6Z34Q7_eZoY9C0kduCs6NzVZQ_8ky5fVsclpEveSF3R6M9t59Xu1l-YZTxEjUTAe8eOTL1SRVBLE3GTeteMpraZkqk1GSgJhPy3gDXR3Cy_-F4MHTrfg6uCDw6c31OA6YDLVmc-qaglYqQ4ReBScFCGWrd1WHKM0FZxERGfS0NutA81irz4kz7j2G9KAv1FEgo_IwzGVLJgyBUcYpuo85ErLTvSTQ_DrxF2SX1-1glNtROvcScvCbQpBaoA1Hz2BNZc6ObFh2T1RO77cSLBT3I6imvG71K8FGY-IwoVDnHm2QRupcm0OvAk4WetYvSyEiMRw6wJQ1sBxia8OUrRX5u6cID9MjR5jmwc11X24mWgqgbctOpAD_2Dnh_M2xQS8kwJ8ye_Zu0t2FjeDw-SA5Gh5-ew12EoDYP3mMvYH32fa5eIsybpa_sG_0LrVxQUg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3rb9MwED-NIR5feGw8wmtGmtAmkVI7DycSX9qOagU2VYJJGxKKHD-0QJtWpJUYfz0-NynrQBrwLUpiKz6fe7_r3f0OYFtRnRgWGl9bOO6HNIn91KTCD2JhmGBt05ZY4HxwGO8fhW-Po-M1eN3UwtiPqOxMlQvi46meKlMzDNBXeD8vJtZR_GJXNG5FqHMhvwJXMXiHjRs6vQ-_KHdpsoh1Iglngnk8W5dMhBZKVqsW6jfY-efsyQsWy1mn_m34vFyXS0r52prP8pb8cYHy8X8Xfgdu1bCVdBZ6dhfWdLkBm53SuuzjM_KCuERS9w_9BlzrNlc3ek07uU04GZ7qcvK9UNrvuiIxRT4VpdwZDHb9blHtqGKKSnlmNdQC310yxDqlilhMTQ6aFr5kMHZNlcjEkJ4ejcgeAth7cNR_87G379d9HXwRUjbzg4SF3IRG8jQPsLCVCbt7lHMpeCQjY9omyhMlGI-5UCwwElGGSVKjFU2VCe7Dejkp9UMgkQhUwmXEZBKGkU5z6z4aJVJtAiqtGfLgpZVdVp_LKnMhd0YzvHlOoFktUA_iZuszWXOkY6uO0eUD28uB0wVNyOVDnje6ldmtwDiNKPVkbj-Sx9bNxICvBw8WuraclMUosST2gK9o4fIFpAtffVIWp442PLSeubV9Hmyf19flQEdF1I4S7Fhgf_Q9oH_zWq-WEjIozB79m7S34Ppwr5-9Hxy-eww3LRJ16fCUP4H12be5fmrR3ix_5g71T0HvUtU |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Phenoxide-Bridged+Zinc%28II%29-Bis%28dipicolylamine%29+Probes+for+Molecular+Imaging+of+Cell+Death&rft.jtitle=Bioconjugate+chemistry&rft.au=Clear%2C+Kasey+J.&rft.au=Harmatys%2C+Kara+M.&rft.au=Rice%2C+Douglas+R.&rft.au=Wolter%2C+William+R.&rft.date=2016-02-17&rft.issn=1043-1802&rft.eissn=1520-4812&rft.volume=27&rft.issue=2&rft.spage=363&rft.epage=375&rft_id=info:doi/10.1021%2Facs.bioconjchem.5b00447&rft.externalDBID=n%2Fa&rft.externalDocID=10_1021_acs_bioconjchem_5b00447 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1043-1802&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1043-1802&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1043-1802&client=summon |