Comparison of the calcium release channel of cardiac and skeletal muscle sarcoplasmic reticulum by target inactivation analysis

• Published in: Biochemistry (Easton) Vol. 28; no. 3; pp. 1319 - 1323
• Main Authors: McGrew, Susan G, Inui, Makoto, Chadwick, Christopher C, Boucek, Robert J, Jung, Chan Y, Fleischer, Sidney
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 07.02.1989
• Subjects: 560120 - Radiation Effects on Biochemicals, Cells, & Tissue Culture; ALKALINE EARTH METAL COMPOUNDS; Alkaloids - metabolism; Animals; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; Calcium Channels - metabolism; Calcium Channels - radiation effects; CALCIUM COMPOUNDS; CARDIOVASCULAR SYSTEM; CATIONS; CELL CONSTITUENTS; CHARGED PARTICLES; ELECTRON BEAMS; ENDOPLASMIC RETICULUM; HEART; HYDROGEN COMPOUNDS; INACTIVATION; IONS; LEPTON BEAMS; MEMBRANE PROTEINS; Microsomes - metabolism; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; MUSCLES; Muscles - metabolism; Myocardium - metabolism; Organ Specificity; ORGANIC COMPOUNDS; ORGANOIDS; ORGANS; PARTICLE BEAMS; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIATION EFFECTS; RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT; RECEPTORS; Receptors, Cholinergic - metabolism; Ryanodine - metabolism; Ryanodine Receptor Calcium Release Channel; SARCOPLASMIC RETICULUM; Sarcoplasmic Reticulum - metabolism; SKELETON; TRITIUM COMPOUNDS

The calcium release channel of sarcoplasmic reticulum which triggers muscle contraction in excitation-contraction coupling has recently been isolated. The channel has been found to be morphologically identical with the feet structures of the junctional face membrane of terminal cisternae and consist...