Methods for the Synthesis of Substituted Azetines
Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from commercially available substrates, allowing fo...
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| Published in | Organic letters Vol. 19; no. 20; pp. 5681 - 5684 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
WASHINGTON
American Chemical Society
20.10.2017
Amer Chemical Soc |
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| Abstract | Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from commercially available substrates, allowing for a straightforward access to a new library of chiral functionalized azetidines and amino alcohols. This original approach was applied to efficiently prepare functionalized azobenzenes, an emerging class of molecules with a large potential in photopharmacology. |
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| AbstractList | Spurred on by the recent emerging interest from the chemical community for unsaturated four-membered heterocycles, an unprecedented approach to nitrogen-containing four-membered rings has been designed. 3,4-Disubstituted 2-azetines were synthesized from commercially available substrates, allowing for a straightforWard access to a new library of chiral functionalized azetidines and amino alcohols. This original approach was applied to efficiently prepare functionalized azobenzenes, an emerging class of molecules with a large potential in photopharmacology. |
| Author | Didier, Dorian Kiw, Yu Min Eisold, Michael Baumann, Andreas N Music, Arif Haas, Geoffrey |
| AuthorAffiliation | Department of Chemistry and Pharmacy Ludwig-Maximilians-University |
| AuthorAffiliation_xml | – name: Department of Chemistry and Pharmacy – name: Ludwig-Maximilians-University |
| Author_xml | – sequence: 1 givenname: Andreas N surname: Baumann fullname: Baumann, Andreas N organization: Ludwig-Maximilians-University – sequence: 2 givenname: Michael orcidid: 0000-0002-2314-3990 surname: Eisold fullname: Eisold, Michael organization: Ludwig-Maximilians-University – sequence: 3 givenname: Arif surname: Music fullname: Music, Arif organization: Ludwig-Maximilians-University – sequence: 4 givenname: Geoffrey surname: Haas fullname: Haas, Geoffrey – sequence: 5 givenname: Yu Min surname: Kiw fullname: Kiw, Yu Min – sequence: 6 givenname: Dorian orcidid: 0000-0002-6358-1485 surname: Didier fullname: Didier, Dorian email: dorian.didier@cup.uni-muenchen.de organization: Ludwig-Maximilians-University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28976769$$D View this record in MEDLINE/PubMed |
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| Keywords | CONVENIENT SYNTHESIS CYCLOADDITION STEREOSELECTIVE-SYNTHESIS AZETIDINES ACCESS SKELETON |
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| Title | Methods for the Synthesis of Substituted Azetines |
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