Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo

• Published in: Nano letters Vol. 13; no. 6; pp. 2528 - 2534
• Main Authors: Wei, Tuo, Liu, Juan, Ma, Huili, Cheng, Qiang, Huang, Yuanyu, Zhao, Jing, Huo, Shuaidong, Xue, Xiangdong, Liang, Zicai, Liang, Xing-Jie
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 12.06.2013
• Subjects: Biocompatibility; Biological and medical sciences; Biomedical materials; Biotechnology; Cell Line, Tumor; Condensed matter: structure, mechanical and thermal properties; Drug Delivery Systems; Exact sciences and technology; Fundamental and applied biological sciences. Psychology; Humans; In Vitro Techniques; In vivo testing; In vivo tests; Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties; Methods. Procedures. Technologies; Micelles; Nanostructure; Nanostructures; Neoplasms - drug therapy; Others; Peptides; Physics; Surfaces and interfaces; thin films and whiskers (structure and nonelectronic properties); Surgical implants; Tumors; Various methods and equipments; tumor-penetrating peptide; micelle; Targeted drug delivery; doxorubicin; neuropilin-1; Encapsulation; Drugs; Nanometer scale; In vivo; Antineoplastic drugs; Peptides; Tumours; Micelles; Cytotoxicity; Drug carrier; Nanostructures; Medical application

Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale...