Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo
Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale...
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| Published in | Nano letters Vol. 13; no. 6; pp. 2528 - 2534 |
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| Main Authors | , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Washington, DC
American Chemical Society
12.06.2013
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| Subjects | |
| Online Access | Get full text |
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| Abstract | Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo. |
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| AbstractList | Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo. Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo. |
| Author | Cheng, Qiang Huo, Shuaidong Xue, Xiangdong Ma, Huili Huang, Yuanyu Liu, Juan Liang, Xing-Jie Zhao, Jing Liang, Zicai Wei, Tuo |
| AuthorAffiliation | National Center for Nanoscience and Technology Peking University |
| AuthorAffiliation_xml | – name: National Center for Nanoscience and Technology – name: Peking University |
| Author_xml | – sequence: 1 givenname: Tuo surname: Wei fullname: Wei, Tuo – sequence: 2 givenname: Juan surname: Liu fullname: Liu, Juan – sequence: 3 givenname: Huili surname: Ma fullname: Ma, Huili – sequence: 4 givenname: Qiang surname: Cheng fullname: Cheng, Qiang – sequence: 5 givenname: Yuanyu surname: Huang fullname: Huang, Yuanyu – sequence: 6 givenname: Jing surname: Zhao fullname: Zhao, Jing – sequence: 7 givenname: Shuaidong surname: Huo fullname: Huo, Shuaidong – sequence: 8 givenname: Xiangdong surname: Xue fullname: Xue, Xiangdong – sequence: 9 givenname: Zicai surname: Liang fullname: Liang, Zicai – sequence: 10 givenname: Xing-Jie surname: Liang fullname: Liang, Xing-Jie email: liangxj@nanoctr.cn |
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| Keywords | tumor-penetrating peptide micelle Targeted drug delivery doxorubicin neuropilin-1 Encapsulation Drugs Nanometer scale In vivo Antineoplastic drugs Peptides Tumours Micelles Cytotoxicity Drug carrier Nanostructures Medical application |
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| SubjectTerms | Biocompatibility Biological and medical sciences Biomedical materials Biotechnology Cell Line, Tumor Condensed matter: structure, mechanical and thermal properties Drug Delivery Systems Exact sciences and technology Fundamental and applied biological sciences. Psychology Humans In Vitro Techniques In vivo testing In vivo tests Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties Methods. Procedures. Technologies Micelles Nanostructure Nanostructures Neoplasms - drug therapy Others Peptides Physics Surfaces and interfaces; thin films and whiskers (structure and nonelectronic properties) Surgical implants Tumors Various methods and equipments |
| Title | Functionalized Nanoscale Micelles Improve Drug Delivery for Cancer Therapy in Vitro and in Vivo |
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