Sequence-Defined Glycopolymer Segments Presenting Mannose: Synthesis and Lectin Binding Affinity

• Published in: Biomacromolecules Vol. 13; no. 6; pp. 1845 - 1852
• Main Authors: Ponader, Daniela, Wojcik, Felix, Beceren-Braun, Figen, Dernedde, Jens, Hartmann, Laura
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 11.06.2012
• Subjects: alkynes; Applied sciences; binding capacity; Binding Sites; chemical composition; concanavalin A; Concanavalin A - chemistry; Exact sciences and technology; hydrophilicity; ligands; mannose; Mannose - chemistry; Organic polymers; Physicochemistry of polymers; polymers; Polymers with particular properties; Polysaccharides - chemical synthesis; Polysaccharides - chemistry; Preparation, kinetics, thermodynamics, mechanism and catalysts; surface plasmon resonance; Lectin; 1,3-Dipolar cycloaddition; Nylon; Aldose; Concanavalin A; Experimental study; Oligomer; Lateral group; Monodispersed polymer; Chemical modification; Aliphatic polymer; Preparation; Solid state reaction; Molecular recognition; Glycoside; Surface plasmon resonance; Peptide synthesis; Aqueous solution

We present for the first time the synthesis of sequence-defined monodisperse glycopolymer segments via solid-phase polymer synthesis. Functional building blocks displaying alkyne moieties and hydrophilic ethylenedioxy units were assembled stepwise on solid phase. The resulting polymer segments were...