Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability

• Published in: Journal of agricultural and food chemistry Vol. 68; no. 44; pp. 12476 - 12484
• Main Authors: Hidalgo-Liberona, Nicole, González-Domínguez, Raúl, Vegas, Esteban, Riso, Patrizia, Del Bo’, Cristian, Bernardi, Stefano, Peron, Gregorio, Guglielmetti, Simone, Gargari, Giorgio, Kroon, Paul Antony, Cherubini, Antonio, Andrés-Lacueva, Cristina
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 04.11.2020
• Subjects: Aged; Aged, 80 and over; Aging - metabolism; bioactive properties; bioavailability; Biological Availability; Diet; Female; food chemistry; Gastrointestinal Microbiome; Humans; intestinal microorganisms; Intestinal Mucosa - metabolism; intestines; Male; metabolism; metabolites; metabolomics; methylation; Middle Aged; Omics Technologies Applied to Agriculture and Food; Permeability; phytochemicals; polyphenols; Polyphenols - metabolism; urine; microbiota; polyphenols; intestinal permeability; aging; metabolomics; bioavailability

Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochemicals may significantly be influenced by interindividual variability factors...