Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability

Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochemicals may significantly be influenced by interindividual variability factors...

Full description

Saved in:
Bibliographic Details
Published inJournal of agricultural and food chemistry Vol. 68; no. 44; pp. 12476 - 12484
Main Authors Hidalgo-Liberona, Nicole, González-Domínguez, Raúl, Vegas, Esteban, Riso, Patrizia, Del Bo’, Cristian, Bernardi, Stefano, Peron, Gregorio, Guglielmetti, Simone, Gargari, Giorgio, Kroon, Paul Antony, Cherubini, Antonio, Andrés-Lacueva, Cristina
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 04.11.2020
Subjects
Aged
Aged, 80 and over
Aging - metabolism
bioactive properties
bioavailability
Biological Availability
Diet
Female
food chemistry
Gastrointestinal Microbiome
Humans
intestinal microorganisms
Intestinal Mucosa - metabolism
intestines
Male
metabolism
metabolites
metabolomics
methylation
Middle Aged
Omics Technologies Applied to Agriculture and Food
Permeability
phytochemicals
polyphenols
Polyphenols - metabolism
urine
microbiota
polyphenols
intestinal permeability
aging
metabolomics
bioavailability
Online AccessGet full text

Cover

Abstract Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochemicals may significantly be influenced by interindividual variability factors affecting their bioavailability and consequent biological activity. In the present study, urine samples collected from older subjects undergoing a crossover intervention trial with polyphenol-rich foods were subjected to metabolomics analysis for investigating the impact of increased IP on the bioavailability of polyphenols. Interestingly, urinary levels of phase II and microbiota-derived metabolites were significantly different between subjects with healthier intestinal barrier integrity and those with increased IP disruption. Our results support that this IP-dependent impaired bioavailability of polyphenols could be attributed to disturbances in the gut microbial metabolism and phase II methylation processes. Furthermore, we also observed that microbiota-derived metabolites could be largely responsible for the biological activity elicited by dietary polyphenols against age-related disrupted IP.
AbstractList Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochemicals may significantly be influenced by interindividual variability factors affecting their bioavailability and consequent biological activity. In the present study, urine samples collected from older subjects undergoing a crossover intervention trial with polyphenol-rich foods were subjected to metabolomics analysis for investigating the impact of increased IP on the bioavailability of polyphenols. Interestingly, urinary levels of phase II and microbiota-derived metabolites were significantly different between subjects with healthier intestinal barrier integrity and those with increased IP disruption. Our results support that this IP-dependent impaired bioavailability of polyphenols could be attributed to disturbances in the gut microbial metabolism and phase II methylation processes. Furthermore, we also observed that microbiota-derived metabolites could be largely responsible for the biological activity elicited by dietary polyphenols against age-related disrupted IP.Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochemicals may significantly be influenced by interindividual variability factors affecting their bioavailability and consequent biological activity. In the present study, urine samples collected from older subjects undergoing a crossover intervention trial with polyphenol-rich foods were subjected to metabolomics analysis for investigating the impact of increased IP on the bioavailability of polyphenols. Interestingly, urinary levels of phase II and microbiota-derived metabolites were significantly different between subjects with healthier intestinal barrier integrity and those with increased IP disruption. Our results support that this IP-dependent impaired bioavailability of polyphenols could be attributed to disturbances in the gut microbial metabolism and phase II methylation processes. Furthermore, we also observed that microbiota-derived metabolites could be largely responsible for the biological activity elicited by dietary polyphenols against age-related disrupted IP.
Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP). However, the efficacy of dietary interventions with these phytochemicals may significantly be influenced by interindividual variability factors affecting their bioavailability and consequent biological activity. In the present study, urine samples collected from older subjects undergoing a crossover intervention trial with polyphenol-rich foods were subjected to metabolomics analysis for investigating the impact of increased IP on the bioavailability of polyphenols. Interestingly, urinary levels of phase II and microbiota-derived metabolites were significantly different between subjects with healthier intestinal barrier integrity and those with increased IP disruption. Our results support that this IP-dependent impaired bioavailability of polyphenols could be attributed to disturbances in the gut microbial metabolism and phase II methylation processes. Furthermore, we also observed that microbiota-derived metabolites could be largely responsible for the biological activity elicited by dietary polyphenols against age-related disrupted IP.
Author Peron, Gregorio
Gargari, Giorgio
Cherubini, Antonio
Guglielmetti, Simone
Kroon, Paul Antony
Andrés-Lacueva, Cristina
Hidalgo-Liberona, Nicole
Bernardi, Stefano
González-Domínguez, Raúl
Vegas, Esteban
Del Bo’, Cristian
Riso, Patrizia
AuthorAffiliation Instituto de Salud Carlos III
Geriatria, Accettazione Geriatrica e Centro di Ricerca per l’Invecchiamento, IRCCS INRCA
CIBER Fragilidad y Envejecimiento Saludable (CIBERfes)
Università degli Studi di Milano, Department of Food
Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Technology Reference Net (XaRTA), Nutrition and Food Safety Research Institute (INSA), Faculty of Pharmacy and Food Sciences
Department of Genetics, Microbiology and Statistics
University of Barcelona
Environmental and Nutritional Sciences (DeFENS)
Norwich Research Park
Quadram Institute Bioscience
AuthorAffiliation_xml – name: Università degli Studi di Milano, Department of Food
– name: Environmental and Nutritional Sciences (DeFENS)
– name: Quadram Institute Bioscience
– name: CIBER Fragilidad y Envejecimiento Saludable (CIBERfes)
– name: Geriatria, Accettazione Geriatrica e Centro di Ricerca per l’Invecchiamento, IRCCS INRCA
– name: Instituto de Salud Carlos III
– name: University of Barcelona
– name: Norwich Research Park
– name: Biomarkers and Nutrimetabolomics Laboratory, Department of Nutrition, Food Sciences and Gastronomy, Food Technology Reference Net (XaRTA), Nutrition and Food Safety Research Institute (INSA), Faculty of Pharmacy and Food Sciences
– name: Department of Genetics, Microbiology and Statistics
Author_xml – sequence: 1
  givenname: Nicole
  surname: Hidalgo-Liberona
  fullname: Hidalgo-Liberona, Nicole
  organization: Instituto de Salud Carlos III
– sequence: 2
  givenname: Raúl
  orcidid: 0000-0002-7640-8833
  surname: González-Domínguez
  fullname: González-Domínguez, Raúl
  email: raul.gonzalez@ub.edu
  organization: Instituto de Salud Carlos III
– sequence: 3
  givenname: Esteban
  surname: Vegas
  fullname: Vegas, Esteban
  organization: University of Barcelona
– sequence: 4
  givenname: Patrizia
  orcidid: 0000-0002-9204-7257
  surname: Riso
  fullname: Riso, Patrizia
  organization: Environmental and Nutritional Sciences (DeFENS)
– sequence: 5
  givenname: Cristian
  surname: Del Bo’
  fullname: Del Bo’, Cristian
  organization: Environmental and Nutritional Sciences (DeFENS)
– sequence: 6
  givenname: Stefano
  surname: Bernardi
  fullname: Bernardi, Stefano
  organization: Environmental and Nutritional Sciences (DeFENS)
– sequence: 7
  givenname: Gregorio
  orcidid: 0000-0002-6007-6184
  surname: Peron
  fullname: Peron, Gregorio
  organization: Instituto de Salud Carlos III
– sequence: 8
  givenname: Simone
  orcidid: 0000-0002-8673-8190
  surname: Guglielmetti
  fullname: Guglielmetti, Simone
  organization: Environmental and Nutritional Sciences (DeFENS)
– sequence: 9
  givenname: Giorgio
  surname: Gargari
  fullname: Gargari, Giorgio
  organization: Environmental and Nutritional Sciences (DeFENS)
– sequence: 10
  givenname: Paul Antony
  orcidid: 0000-0002-9805-6947
  surname: Kroon
  fullname: Kroon, Paul Antony
  organization: Norwich Research Park
– sequence: 11
  givenname: Antonio
  surname: Cherubini
  fullname: Cherubini, Antonio
  organization: Geriatria, Accettazione Geriatrica e Centro di Ricerca per l’Invecchiamento, IRCCS INRCA
– sequence: 12
  givenname: Cristina
  orcidid: 0000-0002-8494-4978
  surname: Andrés-Lacueva
  fullname: Andrés-Lacueva, Cristina
  email: candres@ub.edu.
  organization: Instituto de Salud Carlos III
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33084335$$D View this record in MEDLINE/PubMed
BookMark eNqFkU9v1DAQxS1URLeFOyfkIwey-G_iHGlpy0pFrUQ5W44zYb1y7MVOKu2H4Dvj7W4vSMBpDvN7bzTvnaGTEAMg9JaSJSWMfjQ2LzdmsEtiiWib-gVaUMlIJSlVJ2hBClMpWdNTdJbzhhCiZENeoVPOiRKcywX6tQo2gcnQ41WYIE8uGI_vIY1gOufdtMMu4DvfQ8Lf5m4Ddsp4NW7Nfk5rwBcQYHDWFdXVMDyt44A_O5hM2uH76HfbNYToM-52-GvsZ2_KjR_4YQ0u4QsXzaNx_njrNXo5GJ_hzXGeo-_XVw-XX6rbu5vV5afbyghKp0pQ4Ewa1TaMC6p4I7oO-k61lNZ1bThtBtLarjMN6cFIanuhWE1Vy4eWSkH4OXp_8N2m-HMuX-vRZQvemwBxzppJJhhXkrD_o0KyVhHF64K-O6JzN0Kvt8mNJQT9nHYB6gNgU8w5waCtm0ocMUyphKAp0ftadalV72vVx1qLkPwhfPb-h-TDQfK0iXMqvea_478B3xm2qw
CitedBy_id crossref_primary_10_5604_01_3001_0053_4033
crossref_primary_10_1016_j_ajcnut_2023_04_013
crossref_primary_10_3390_ijms25063264
crossref_primary_10_3389_fbioe_2021_753898
crossref_primary_10_1007_s40520_024_02707_9
crossref_primary_10_1039_D4FO01162G
crossref_primary_10_1007_s00394_021_02680_3
crossref_primary_10_1016_j_archger_2024_105640
crossref_primary_10_3390_antiox12010123
crossref_primary_10_1371_journal_pone_0277453
crossref_primary_10_1016_j_foodchem_2021_131877
crossref_primary_10_1016_j_foodhyd_2022_108165
crossref_primary_10_1038_s41575_022_00605_x
crossref_primary_10_3390_antiox12040979
crossref_primary_10_1016_j_fbio_2021_101500
crossref_primary_10_1016_j_foodchem_2021_130928
crossref_primary_10_3390_life11070698
crossref_primary_10_1002_mnfr_202100670
crossref_primary_10_1080_10408398_2021_1995321
crossref_primary_10_3389_fnut_2023_1120168
crossref_primary_10_1007_s12603_023_1929_6
crossref_primary_10_1021_acs_analchem_3c03660
crossref_primary_10_1016_j_jot_2024_11_003
crossref_primary_10_1039_D4FO03950E
crossref_primary_10_1002_mnfr_202400526
crossref_primary_10_1039_D1FO04029D
crossref_primary_10_1021_acs_jafc_1c07432
crossref_primary_10_3390_antiox12122103
crossref_primary_10_1002_ctd2_170
crossref_primary_10_3390_metabo12040302
crossref_primary_10_1016_j_foodres_2022_111632
crossref_primary_10_3390_foods10040839
crossref_primary_10_1111_ijfs_15724
Cites_doi 10.1111/j.1348-0421.2003.tb03418.x
10.1093/databa/baaa033
10.1093/eurheartj/eht271
10.1016/j.jamda.2017.05.018
10.1371/annotation/df45912f-d15c-44ab-8312-e7ec0607604d
10.1097/MOG.0000000000000243
10.1371/journal.pone.0210728
10.1111/j.1462-2920.2009.01900.x
10.3920/BM2014.0041
10.2337/db05-1593
10.3233/NHA-170030
10.1080/089106001750071690
10.1093/advances/nmz061
10.1007/s00018-012-1070-x
10.1080/10408398.2018.1546669
10.3390/ijms10115002
10.1186/1743-7075-9-105
10.1021/acs.jafc.8b07023
10.1038/ncpgasthep0259
10.3390/nu12041082
10.1038/s41366-020-0628-1
10.1186/s12877-020-1472-9
10.1073/pnas.1000097107
10.1002/mnfr.201900952
10.1080/17512433.2019.1612744
10.3233/NUA-140038
10.1016/j.cgh.2012.08.012
10.1017/S000711450888871X
10.1017/S002966512000484X
10.3389/fmed.2018.00349
10.1016/j.tifs.2020.03.036
10.3389/fncel.2015.00392
10.1021/jf902107d
10.1586/17474124.2015.1092872
10.1186/s12877-018-0767-6
10.1017/S0007114509991553
10.1136/gut.48.2.198
10.1021/acs.jafc.9b02283
10.3390/metabo10060229
10.1099/0022-1317-51-5-448
10.1021/ac051495j
10.1111/j.1749-6632.2000.tb06651.x
10.2174/1389200023337586
10.4291/wjgp.v3.i1.27
10.3390/nu10111718
10.1186/1471-2180-9-123
10.1186/s12876-014-0189-7
10.3389/fimmu.2015.00612
10.1039/C8FO01962B
10.2174/1573401311309020002
10.1021/acs.jafc.9b01687
ContentType Journal Article
Copyright 2020 American Chemical Society
Copyright_xml – notice: 2020 American Chemical Society
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
DOI 10.1021/acs.jafc.0c04976
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList MEDLINE - Academic
AGRICOLA

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Agriculture
EISSN 1520-5118
EndPage 12484
ExternalDocumentID 33084335
10_1021_acs_jafc_0c04976
b115615457
Genre Randomized Controlled Trial
Journal Article
GroupedDBID -
55A
5GY
5VS
7~N
85S
AABXI
ABFLS
ABMVS
ABUCX
ACGFS
ACJ
ACS
AEESW
AENEX
AFEFF
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
CS3
DU5
EBS
ED
ED~
F5P
GNL
GX1
IH9
JG
JG~
LG6
P2P
ROL
TWZ
UI2
VF5
VG9
W1F
WH7
X
---
-~X
.K2
4.4
AAHBH
AAYXX
ABBLG
ABJNI
ABLBI
ABQRX
ACGFO
ADHLV
AGXLV
AHGAQ
BAANH
CITATION
CUPRZ
GGK
CGR
CUY
CVF
ECM
EIF
NPM
7X8
7S9
L.6
ID FETCH-LOGICAL-a411t-41e325a89723418374bbedb8911666a317f09cbba70dea51cd48261893f915403
IEDL.DBID ACS
ISSN 0021-8561
1520-5118
IngestDate Fri Jul 11 11:34:08 EDT 2025
Fri Jul 11 11:53:21 EDT 2025
Thu Jan 02 22:57:15 EST 2025
Thu Apr 24 23:11:20 EDT 2025
Tue Jul 01 03:34:00 EDT 2025
Fri Nov 06 14:15:01 EST 2020
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 44
Keywords microbiota
polyphenols
intestinal permeability
aging
metabolomics
bioavailability
Language English
License https://doi.org/10.15223/policy-029
https://doi.org/10.15223/policy-037
https://doi.org/10.15223/policy-045
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a411t-41e325a89723418374bbedb8911666a317f09cbba70dea51cd48261893f915403
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ObjectType-Undefined-3
ORCID 0000-0002-9204-7257
0000-0002-6007-6184
0000-0002-8673-8190
0000-0002-9805-6947
0000-0002-8494-4978
0000-0002-7640-8833
OpenAccessLink http://hdl.handle.net/2434/804397
PMID 33084335
PQID 2452980836
PQPubID 23479
PageCount 9
ParticipantIDs proquest_miscellaneous_2524238502
proquest_miscellaneous_2452980836
pubmed_primary_33084335
crossref_citationtrail_10_1021_acs_jafc_0c04976
crossref_primary_10_1021_acs_jafc_0c04976
acs_journals_10_1021_acs_jafc_0c04976
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
7~N
ACJ
VG9
W1F
ACS
AEESW
AFEFF
ABMVS
ABUCX
IH9
AQSVZ
ED~
UI2
CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-11-04
PublicationDateYYYYMMDD 2020-11-04
PublicationDate_xml – month: 11
  year: 2020
  text: 2020-11-04
  day: 04
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
PublicationTitle Journal of agricultural and food chemistry
PublicationTitleAlternate J. Agric. Food Chem
PublicationYear 2020
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref9/cit9
ref45/cit45
ref3/cit3
ref27/cit27
ref16/cit16
ref23/cit23
ref8/cit8
ref31/cit31
ref2/cit2
ref34/cit34
ref37/cit37
ref20/cit20
ref48/cit48
ref17/cit17
ref10/cit10
ref35/cit35
ref19/cit19
ref21/cit21
ref42/cit42
ref46/cit46
ref49/cit49
ref13/cit13
ref24/cit24
ref38/cit38
ref50/cit50
ref6/cit6
ref36/cit36
ref18/cit18
ref11/cit11
ref25/cit25
ref29/cit29
ref32/cit32
ref39/cit39
ref14/cit14
ref5/cit5
ref51/cit51
ref43/cit43
ref28/cit28
ref40/cit40
ref26/cit26
ref12/cit12
ref15/cit15
ref41/cit41
ref22/cit22
ref33/cit33
ref4/cit4
ref30/cit30
ref47/cit47
ref1/cit1
ref44/cit44
ref7/cit7
33686863 - J Agric Food Chem. 2021 Mar 9
References_xml – ident: ref43/cit43
  doi: 10.1111/j.1348-0421.2003.tb03418.x
– ident: ref37/cit37
  doi: 10.1093/databa/baaa033
– ident: ref6/cit6
  doi: 10.1093/eurheartj/eht271
– ident: ref34/cit34
  doi: 10.1016/j.jamda.2017.05.018
– ident: ref44/cit44
  doi: 10.1371/annotation/df45912f-d15c-44ab-8312-e7ec0607604d
– ident: ref3/cit3
  doi: 10.1097/MOG.0000000000000243
– ident: ref32/cit32
  doi: 10.1371/journal.pone.0210728
– ident: ref41/cit41
  doi: 10.1111/j.1462-2920.2009.01900.x
– ident: ref21/cit21
  doi: 10.3920/BM2014.0041
– ident: ref33/cit33
  doi: 10.2337/db05-1593
– ident: ref11/cit11
  doi: 10.3233/NHA-170030
– ident: ref45/cit45
  doi: 10.1080/089106001750071690
– ident: ref12/cit12
  doi: 10.1093/advances/nmz061
– ident: ref2/cit2
  doi: 10.1007/s00018-012-1070-x
– ident: ref19/cit19
  doi: 10.1080/10408398.2018.1546669
– ident: ref49/cit49
  doi: 10.3390/ijms10115002
– ident: ref23/cit23
  doi: 10.1186/1743-7075-9-105
– ident: ref26/cit26
  doi: 10.1021/acs.jafc.8b07023
– ident: ref4/cit4
  doi: 10.1038/ncpgasthep0259
– ident: ref5/cit5
  doi: 10.3390/nu12041082
– ident: ref27/cit27
  doi: 10.1038/s41366-020-0628-1
– ident: ref28/cit28
  doi: 10.1186/s12877-020-1472-9
– ident: ref39/cit39
  doi: 10.1073/pnas.1000097107
– ident: ref18/cit18
  doi: 10.1002/mnfr.201900952
– ident: ref8/cit8
  doi: 10.1080/17512433.2019.1612744
– ident: ref50/cit50
  doi: 10.3233/NUA-140038
– ident: ref29/cit29
  doi: 10.1016/j.cgh.2012.08.012
– ident: ref48/cit48
  doi: 10.1017/S000711450888871X
– ident: ref36/cit36
  doi: 10.1017/S002966512000484X
– ident: ref13/cit13
  doi: 10.3389/fmed.2018.00349
– ident: ref20/cit20
  doi: 10.1016/j.tifs.2020.03.036
– ident: ref7/cit7
  doi: 10.3389/fncel.2015.00392
– ident: ref38/cit38
  doi: 10.1021/jf902107d
– ident: ref10/cit10
  doi: 10.1586/17474124.2015.1092872
– ident: ref35/cit35
  doi: 10.1186/s12877-018-0767-6
– ident: ref42/cit42
  doi: 10.1017/S0007114509991553
– ident: ref47/cit47
  doi: 10.1136/gut.48.2.198
– ident: ref15/cit15
  doi: 10.1021/acs.jafc.9b02283
– ident: ref31/cit31
  doi: 10.3390/metabo10060229
– ident: ref46/cit46
  doi: 10.1099/0022-1317-51-5-448
– ident: ref30/cit30
  doi: 10.1021/ac051495j
– ident: ref9/cit9
  doi: 10.1111/j.1749-6632.2000.tb06651.x
– ident: ref51/cit51
  doi: 10.2174/1389200023337586
– ident: ref22/cit22
  doi: 10.4291/wjgp.v3.i1.27
– ident: ref25/cit25
  doi: 10.3390/nu10111718
– ident: ref40/cit40
  doi: 10.1186/1471-2180-9-123
– ident: ref1/cit1
  doi: 10.1186/s12876-014-0189-7
– ident: ref17/cit17
  doi: 10.3389/fimmu.2015.00612
– ident: ref24/cit24
  doi: 10.1039/C8FO01962B
– ident: ref16/cit16
  doi: 10.2174/1573401311309020002
– ident: ref14/cit14
  doi: 10.1021/acs.jafc.9b01687
– reference: 33686863 - J Agric Food Chem. 2021 Mar 9;:
SSID ssj0008570
Score 2.5053034
Snippet Polyphenols have great potential in regulating intestinal health and ameliorating pathological conditions related to increased intestinal permeability (IP)....
SourceID proquest
pubmed
crossref
acs
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 12476
SubjectTerms Aged
Aged, 80 and over
Aging - metabolism
bioactive properties
bioavailability
Biological Availability
Diet
Female
food chemistry
Gastrointestinal Microbiome
Humans
intestinal microorganisms
Intestinal Mucosa - metabolism
intestines
Male
metabolism
metabolites
metabolomics
methylation
Middle Aged
Omics Technologies Applied to Agriculture and Food
Permeability
phytochemicals
polyphenols
Polyphenols - metabolism
urine
Title Increased Intestinal Permeability in Older Subjects Impacts the Beneficial Effects of Dietary Polyphenols by Modulating Their Bioavailability
URI http://dx.doi.org/10.1021/acs.jafc.0c04976
https://www.ncbi.nlm.nih.gov/pubmed/33084335
https://www.proquest.com/docview/2452980836
https://www.proquest.com/docview/2524238502
Volume 68
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT9wwELZaemkPQJ8sfciV2kMPWeLE3jjHBYpoJVqkgsQtGj-CtqwStM4iLf-B_8xMErbqa8U1smPZnhl_4xl_w9gHZWPjnc8jYTxE0guIwMlR5ACkdqV0paLXyEffRoen8uuZOvtFk_NnBD8RO2DD8CeUdhhbRLPZ6CF7lIx0Ro7WeO_H0uoSUXuXziEijaCgD0n-6w90ENnw-0H0H3TZnjIHG125otCSE1JyycVw3pihvf6buvEeE9hk6z3Y5ONOOp6yB756xp6Mz2c94YZ_zm7QQFBeunecLgdR4anHMdpr3zF4L_ik4t-pljdHI0O3NoF_aZ9WBo7gke-isexYKHjHhBx4XfL9iW9gtuDH9XRBWWT1NHCz4Ee1a8uFVef8hCIUfHdSwxVMpv1YL9jpweeTvcOoL9EQgRSiiaTwaaJAU-0yidYhkwa33mg0oegXAYKTMs6tMZDFzoMS1kn0ZwSCpDJH8BanL9laVVd-i3GXlSrNHeIha2UpjbYKZE6MblpbcGbAPuJKFr2KhaKNnieiaD_i8hb98g7Yzt2-FrbnOadyG9MVPT4te1x2HB8r2r6_E5UCFZGiK1D5eh6KNoStiex7RRtF8FWrOBmwV52cLUdM01jLNFXb95zna_Y4Id-frrjlG7bWzOb-LQKkxrxrNeMWttwNpA
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lj9MwEB4tywE48H6Up5HgwCHdOLFb59hdWHVhu6ygK-0t8iurQpWgOkUq_4H_zEySFoGggqvlV5zx-PPM-BuAF9LGxjufRdx4HQnPdaSdGEROa6FcIVwh6TXy5GQwPhNvz-X5DvD1WxicRMCeQuPE_8kuwPeo7JMubD-2CGqHg0twGbFIQvet0cHHjfIlvvY2qoNHCrFB55n8Uw90Htnw63n0F5DZHDaHN-DDZppNjMnn_rI2ffvtNwbH__qOm3C9g55s1MrKLdjx5W24NrpYdPQb_g58R3VBUereMTIV4vanFqeovX3L571is5K9p8zeDFUO2XACO2oeWgaGUJLto-psOSlYy4scWFWw1zNf68WKnVbzFcWUVfPAzIpNKtckDysv2JT8FWx_VumvejbvxroLZ4dvpgfjqEvYEGnBeR0J7tNEakWZzATqiqEwKAhGoULFW5JGqFLEmTVGD2PnteTWCbzdcIRMRYZQLk7vwW5Zlf4BMDcsZJo5REfWikIYZaUWGfG7KWW1Mz14iSuZdxsu5I0vPeF5U4jLm3fL24O99e_Nbcd6Tsk35ltavNq0-NIyfmyp-3wtMTluS_K16NJXy5A3Dm1F1N9b6kgCs0rGSQ_ut-K2GTFNYyXSVD78x-98BlfG08lxfnx08u4RXE3IKkDGb_EYduvF0j9B6FSbp81m-QEdpRYF
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1LbxMxELZKkRAcWt4N5WEkOHDYdJ21E-8xbYlaoCUSLept5WcVGu1W8aZS-A_8Z2a8m0ggiOBq-bXe8fjzzPgbQt4Ik2pnXZ4w7VTCHVOJsryfWKW4tJ5bL_A18slp_-icf7gQFxtELN_CwCQC9BSiEx939bX1LcMA28Pyb8qbbmoA2A76t8ht9NrhnWt48GWlgJGzvYnsYIkEfNB6J__UA55JJvx6Jv0FaMYDZ7RNvq6mGuNMrrrzWnfN999YHP_7W-6TrRaC0mEjMw_IhisfknvDy1lLw-EekR-gNjBa3VmKJkNQA9hiDFrcNbzeCzop6WfM8E1B9aAtJ9Dj-OAyUICUdB9UaMNNQRt-5EArTw8nrlazBR1X0wXGllXTQPWCnlQ2JhErL-kZ-i3o_qRSN2oybcd6TM5H788OjpI2cUOiOGN1wpnLekJJzGjGQWcMuAaB0BIUK9yWFEAWn-ZGazVIrVOCGcvhlsMAOvkcIF2aPSGbZVW6HULtwIsst4CSjOGea2mE4jnyvElplNUd8hZWsmg3XiiiT73HilgIy1u0y9she8tfXJiW_RyTcEzXtHi3anHdMH-sqft6KTUFbE_0uajSVfNQRMe2RArwNXUEglop0l6HPG1EbjVilqWSZ5l49o_f-YrcGR-Oik_Hpx93yd0eGgfQBs6fk816NncvAEHV-mXcLz8BBzIYiA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Increased+Intestinal+Permeability+in+Older+Subjects+Impacts+the+Beneficial+Effects+of+Dietary+Polyphenols+by+Modulating+Their+Bioavailability&rft.jtitle=Journal+of+agricultural+and+food+chemistry&rft.au=Hidalgo-Liberona%2C+Nicole&rft.au=Gonza%CC%81lez-Domi%CC%81nguez%2C+Rau%CC%81l&rft.au=Vegas%2C+Esteban&rft.au=Riso%2C+Patrizia&rft.date=2020-11-04&rft.pub=American+Chemical+Society&rft.issn=0021-8561&rft.eissn=1520-5118&rft.volume=68&rft.issue=44&rft.spage=12476&rft.epage=12484&rft_id=info:doi/10.1021%2Facs.jafc.0c04976&rft.externalDocID=b115615457
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-8561&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-8561&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-8561&client=summon