Long-Term Use of Antidepressants for Depressive Disorders and the Risk of Diabetes Mellitus

• Published in: The American journal of psychiatry Vol. 166; no. 5; pp. 591 - 598
• Main Authors: Andersohn, Frank, Schade, René, Suissa, Samy, Garbe, Edeltraut
• Format: Journal Article
• Language: English
• Published: Arlington, VA American Psychiatric Association 01.05.2009
• Subjects: Adult and adolescent clinical studies; Amitriptyline - adverse effects; Antidepressive Agents, Tricyclic - adverse effects; Biological and medical sciences; Body Mass Index; Case-Control Studies; Cyclohexanols - adverse effects; Depression; Depressive Disorder - drug therapy; Diabetes; Diabetes Mellitus - chemically induced; Diabetes Mellitus - epidemiology; Diabetes. Impaired glucose tolerance; Drugs; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Family physicians; Female; Fluvoxamine - adverse effects; Humans; Incidence; Male; Medical sciences; Mental depression; Middle Aged; Mood disorders; Neuropharmacology; Paroxetine - adverse effects; Patients; Pharmacology. Drug treatments; Prescriptions; Prevention programs; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease); Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychopharmacology; Risk Factors; Serotonin Uptake Inhibitors - adverse effects; Time Factors; United Kingdom - epidemiology; Venlafaxine Hydrochloride; Endocrinopathy; Mood disorder; Psychotropic; Diabetes mellitus; Risk factor; Antidepressant agent; Depression; Long term

Objective: Use of antidepressants has been reported to cause considerable weight gain. The aim of this study was to assess the risk of diabetes mellitus associated with antidepressant treatment and to examine whether the risk is influenced by treatment duration or daily dose. Method: This was a nest...