Phase Separation of Lipid Microdomains Controlled by Polymerized Lipid Bilayer Matrices

• Published in: Langmuir Vol. 26; no. 6; pp. 4126 - 4129
• Main Authors: Okazaki, Takashi, Tatsu, Yoshiro, Morigaki, Kenichi
• Format: Journal Article
• Language: English
• Published: Washington, DC American Chemical Society 16.03.2010
• Subjects: Biological Interfaces: Biocolloids, Biomolecular and Biomimetic Materials; Chemistry; Colloidal state and disperse state; Exact sciences and technology; General and physical chemistry; Lipid Bilayers; Membranes; Microscopy, Fluorescence; Phospholipids - chemistry; Polymers - chemistry; Surface physical chemistry; Vesicle; Self assembly; Growth; Ternary mixture; Phospholipid; Polymerization; Lipids; Polymer; Bilayer; Cholesterol; Protein; Solid; Design; Thickness; Geometry; Substrate; Liquid; Phase separation; Membrane; Models

We developed a micropatterned model biological membrane on a solid substrate that can induce phase separation of lipid microdomains in a designed geometry. Micropatterned lipid bilayers were generated by the photolithographic polymerization of a diacetylene phospholipid, 1,2-bis(10,12-tricosadiynoyl...