Furan Metabolites Are Elevated in Users of Various Tobacco Products and Cannabis

Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An est...

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Published inChemical research in toxicology Vol. 36; no. 2; pp. 157 - 161
Main Authors Vevang, Karin R., Zhang, Lin, Grill, Alex E., Hatsukami, Dorothy K., Meier, Ellen, Nomura, Sarah Oppeneer, Robien, Kim, Peterson, Lisa A.
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 20.02.2023
Subjects
Biomarkers - urine
Cannabis - metabolism
Electronic Nicotine Delivery Systems
Furans - metabolism
Humans
Nicotiana - metabolism
Tobacco Products
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Summary:Humans are exposed to furan, a toxicant and possible human carcinogen, through multiple sources including diet and tobacco smoke. The urinary metabolites of furan are derived from the reaction of its toxic metabolite with protein nucleophiles and are biomarkers of exposure and potential harm. An established isotopic dilution liquid-chromatography mass spectrometry method was used to measure these biomarkers in urine from users of e-cigarettes, cannabis, and/or combustible tobacco with/without reduced nicotine levels. Amounts of furan mercapturic acid metabolites were higher in these individuals relative to nonsmokers, indicating that they may be at risk for potential furan-derived toxicities.
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Alex Grill’s current address: Waters Corporation, 34 Maple St Milford MA 01757.
The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript.
Sarah O. Nomura’s current address: Department of Lab Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455.
Author Contributions
ISSN:0893-228X
1520-5010
DOI:10.1021/acs.chemrestox.2c00412