Mass-Spectrometry Analysis of Mixed-Breath, Isolated-Bronchial-Breath, and Gastric-Endoluminal-Air Volatile Fatty Acids in Esophagogastric Cancer

• Published in: Analytical chemistry (Washington) Vol. 91; no. 5; pp. 3740 - 3746
• Main Authors: Adam, Mina E, Fehervari, Matyas, Boshier, Piers R, Chin, Sung-Tong, Lin, Geng-Ping, Romano, Andrea, Kumar, Sacheen, Hanna, George B
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 05.03.2019
• Subjects: Acetone; air; biopsy; Breath tests; Breath Tests - methods; Butyric acid; Cancer; Case-Control Studies; Chemistry; confidence interval; Confidence intervals; Esophageal Neoplasms - diagnosis; Fatty acids; Fatty Acids, Volatile - analysis; gas chromatography-mass spectrometry; Gas Chromatography-Mass Spectrometry - methods; Gastrointestinal system; Gastrointestinal tract; Headspace; headspace analysis; Hexanoic acid; Humans; In vivo methods and tests; Lungs; Mass Spectrometry - methods; neoplasms; patients; ROC Curve; Spectrometry; Stomach Neoplasms - diagnosis; tissues; Volatile fatty acids

A noninvasive breath test has the potential to improve survival from esophagogastric cancer by facilitating earlier detection. This study aimed to investigate the production of target volatile fatty acids (VFAs) in esophagogastric cancer through analysis of the ex vivo headspace above underivatized...