Investigation of Environmental Pollutant-Induced Lung Inflammation and Injury in a 3D Coculture-Based Microfluidic Pulmonary Alveolus System

• Published in: Analytical chemistry (Washington) Vol. 92; no. 10; pp. 7200 - 7208
• Main Authors: Zhang, Fen, Liu, Wenming, Zhou, Sisi, Jiang, Ling, Wang, Kan, Wei, Yuanqing, Liu, Anran, Wei, Wei, Liu, Songqin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 19.05.2020
• Subjects: Alveoli; analytical chemistry; Benzopyrenes - adverse effects; Benzopyrenes - chemistry; Biomimetics; Cells, Cultured; Chemistry; coculture; Coculture Techniques; Computer simulation; Cytokines - analysis; Cytokines - metabolism; drugs; Endothelium; Environmental impact; Environmental monitoring; Environmental Pollutants - adverse effects; Environmental Pollutants - chemistry; Epithelium; Human pathology; Humans; Inflammation; Injuries; Injury analysis; Interfaces; Lungs; Microenvironments; Microfluidic Analytical Techniques; Microfluidics; Microscopy, Confocal; Microvasculature; Molecular Structure; Monoculture; Nicotine - adverse effects; Nicotine - chemistry; pathophysiology; Pneumonia - chemically induced; Pneumonia - metabolism; Pneumonia - pathology; Pollutants; pollution; Pulmonary Alveoli - drug effects; Pulmonary Alveoli - metabolism; Pulmonary Alveoli - pathology; Reactive Oxygen Species - metabolism; Synergistic effect; Tissue engineering; viability

The health impact of environmental pollution involving an increase in human diseases has been subject to extensive study in recent decades. The methodology in biomimetic investigation of these pathophysiologic events is still in progress to uncover the gaps in knowledge associated with pollution and...