In Vitro/In Vivo Electrochemical Detection of Pt(II) Species

The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for simple, inexpensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the u...

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Published inAnalytical chemistry (Washington) Vol. 94; no. 12; pp. 4901 - 4905
Main Authors Vaneev, Alexander N, Gorelkin, Petr V, Krasnovskaya, Olga O, Akasov, Roman A, Spector, Daniil V, Lopatukhina, Elena V, Timoshenko, Roman V, Garanina, Anastasiia S, Zhang, Yanjun, Salikhov, Sergey V, Edwards, Christopher R. W, Klyachko, Natalia L, Takahashi, Yasufumi, Majouga, Alexander G, Korchev, Yuri E, Erofeev, Alexander S
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 29.03.2022
Subjects
Adenocarcinoma
Analytical chemistry
Animals
Antineoplastic Agents
Antineoplastic drugs
Biological models (mathematics)
Breast
breasts
carbon
Cell culture
chemical species
Chemistry
Chemotherapy
Cisplatin
Cisplatin - chemistry
Cisplatin - pharmacology
Concentration gradient
Drug development
Drugs
Electrochemical analysis
Electrochemistry
Humans
intravenous injection
MCF-7 Cells
Mice
Platinum
Prodrugs - chemistry
Solid tumors
Species
Spheroids
Tissue Distribution
Tumors
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Abstract The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for simple, inexpensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the use of platinized carbon nanoelectrodes (PtNEs) for the electrochemical detection of platinum-based drugs in various biological models, including single cells and tumor spheroids in vitro and inside solid tumors in vivo. We have demonstrated the quantitative direct detection of Pt­(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and a cisplatin-based DNP prodrug. To realize the potential of this technique in advanced tumor models, we measured Pt­(II) in 3D tumor spheroids in vitro and in tumor-bearing mice in vivo. The concentration gradient of Pt­(II) species correlated with the distance from the sample surface in MCF-7 tumor spheroids. We then performed the detection of Pt­(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We found that there was deeper penetration of DNP in comparison to cisplatin. This research demonstrates a minimally invasive, real-time electrochemical technique for the study of platinum-based drugs.
AbstractList The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for simple, inexpensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the use of platinized carbon nanoelectrodes (PtNEs) for the electrochemical detection of platinum-based drugs in various biological models, including single cells and tumor spheroids in vitro and inside solid tumors in vivo. We have demonstrated the quantitative direct detection of Pt(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and a cisplatin-based DNP prodrug. To realize the potential of this technique in advanced tumor models, we measured Pt(II) in 3D tumor spheroids in vitro and in tumor-bearing mice in vivo. The concentration gradient of Pt(II) species correlated with the distance from the sample surface in MCF-7 tumor spheroids. We then performed the detection of Pt(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We found that there was deeper penetration of DNP in comparison to cisplatin. This research demonstrates a minimally invasive, real-time electrochemical technique for the study of platinum-based drugs.
The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for simple, inexpensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the use of platinized carbon nanoelectrodes (PtNEs) for the electrochemical detection of platinum-based drugs in various biological models, including single cells and tumor spheroids in vitro and inside solid tumors in vivo. We have demonstrated the quantitative direct detection of Pt­(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and a cisplatin-based DNP prodrug. To realize the potential of this technique in advanced tumor models, we measured Pt­(II) in 3D tumor spheroids in vitro and in tumor-bearing mice in vivo. The concentration gradient of Pt­(II) species correlated with the distance from the sample surface in MCF-7 tumor spheroids. We then performed the detection of Pt­(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We found that there was deeper penetration of DNP in comparison to cisplatin. This research demonstrates a minimally invasive, real-time electrochemical technique for the study of platinum-based drugs.
The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for simple, inexpensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the use of platinized carbon nanoelectrodes (PtNEs) for the electrochemical detection of platinum-based drugs in various biological models, including single cells and tumor spheroids and inside solid tumors . We have demonstrated the quantitative direct detection of Pt(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and a cisplatin-based DNP prodrug. To realize the potential of this technique in advanced tumor models, we measured Pt(II) in 3D tumor spheroids and in tumor-bearing mice . The concentration gradient of Pt(II) species correlated with the distance from the sample surface in MCF-7 tumor spheroids. We then performed the detection of Pt(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We found that there was deeper penetration of DNP in comparison to cisplatin. This research demonstrates a minimally invasive, real-time electrochemical technique for the study of platinum-based drugs.
The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for simple, inexpensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the use of platinized carbon nanoelectrodes (PtNEs) for the electrochemical detection of platinum-based drugs in various biological models, including single cells and tumor spheroids in vitro and inside solid tumors in vivo. We have demonstrated the quantitative direct detection of Pt(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and a cisplatin-based DNP prodrug. To realize the potential of this technique in advanced tumor models, we measured Pt(II) in 3D tumor spheroids in vitro and in tumor-bearing mice in vivo. The concentration gradient of Pt(II) species correlated with the distance from the sample surface in MCF-7 tumor spheroids. We then performed the detection of Pt(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We found that there was deeper penetration of DNP in comparison to cisplatin. This research demonstrates a minimally invasive, real-time electrochemical technique for the study of platinum-based drugs.The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for simple, inexpensive, sensitive, and selective detection of various analytes in tumors are of great importance. In this paper we propose the use of platinized carbon nanoelectrodes (PtNEs) for the electrochemical detection of platinum-based drugs in various biological models, including single cells and tumor spheroids in vitro and inside solid tumors in vivo. We have demonstrated the quantitative direct detection of Pt(II) in breast adenocarcinoma MCF-7 cells treated with cisplatin and a cisplatin-based DNP prodrug. To realize the potential of this technique in advanced tumor models, we measured Pt(II) in 3D tumor spheroids in vitro and in tumor-bearing mice in vivo. The concentration gradient of Pt(II) species correlated with the distance from the sample surface in MCF-7 tumor spheroids. We then performed the detection of Pt(II) species in tumor-bearing mice treated intravenously with cisplatin and DNP. We found that there was deeper penetration of DNP in comparison to cisplatin. This research demonstrates a minimally invasive, real-time electrochemical technique for the study of platinum-based drugs.
Author Vaneev, Alexander N
Zhang, Yanjun
Klyachko, Natalia L
Takahashi, Yasufumi
Timoshenko, Roman V
Salikhov, Sergey V
Lopatukhina, Elena V
Erofeev, Alexander S
Krasnovskaya, Olga O
Akasov, Roman A
Edwards, Christopher R. W
Garanina, Anastasiia S
Korchev, Yuri E
Gorelkin, Petr V
Spector, Daniil V
Majouga, Alexander G
AuthorAffiliation Sechenov First Moscow State Medical University
Chemistry Department
Department of Medicine
National University of Science and Technology (MISIS)
Federal Scientific Research Centre “Crystallography and Photonics”
Nano Life Science Institute (WPI-NanoLSI)
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Snippet The biodistribution of chemotherapy compounds within tumor tissue is one of the main challenges in the development of antineoplastic drugs, and techniques for...
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SubjectTerms Adenocarcinoma
Analytical chemistry
Animals
Antineoplastic Agents
Antineoplastic drugs
Biological models (mathematics)
Breast
breasts
carbon
Cell culture
chemical species
Chemistry
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Title In Vitro/In Vivo Electrochemical Detection of Pt(II) Species
URI http://dx.doi.org/10.1021/acs.analchem.2c00136
https://www.ncbi.nlm.nih.gov/pubmed/35285614
https://www.proquest.com/docview/2648606674
https://www.proquest.com/docview/2638941066
https://www.proquest.com/docview/2648870629
Volume 94
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