Self-Assembly of Luminescent Gold Nanoparticles with Sensitive pH-Stimulated Structure Transformation and Emission Response toward Lysosome Escape and Intracellular Imaging

• Published in: Analytical chemistry (Washington) Vol. 91; no. 13; pp. 8237 - 8243
• Main Authors: Zhu, Jiayi, He, Kui, Dai, Zhiyi, Gong, Lingshan, Zhou, Tingyao, Liang, Huarun, Liu, Jinbin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 02.07.2019
• Subjects: Cationic polymerization; Chemistry; Chitosan; Cytoplasm; Emission; Emissions; Gold; image analysis; Internalization; Intracellular; isoelectric point; Luminescence; lysosomes; nanogold; Nanoparticles; Nanostructure; Optical properties; pH effects; Polymers; Precision medicine; Self-assembly; Surface charge

Ultrasmall luminescent gold nanoparticles (AuNPs, d < 3.0 nm) with distinct optical properties and good biocompatibilities hold enormous promise for advanced disease theranostics. However, ultrasmall AuNPs generally show low cellular interaction and are hardly ever transported into the specific s...