Well-Ordered Au Nanoarray for Sensitive and Reproducible Detection of Hepatocellular Carcinoma-Associated miRNA via CHA-Assisted SERS/Fluorescence Dual-Mode Sensing

• Published in: Analytical chemistry (Washington) Vol. 95; no. 14; pp. 5955 - 5966
• Main Authors: Huang, Xueqin, Tian, Hemi, Huang, Lei, Chen, Qiuxia, Yang, Yingqi, Zeng, Runmin, Xu, Jun, Chen, Shanze, Zhou, Xia, Liu, Guangqiang, Li, Haoyu, Zhang, Yuan, Zhang, Jianglin, Zheng, Junxia, Cai, Huaihong, Zhou, Haibo
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 11.04.2023
• Subjects: adsorption; analytical chemistry; Biomarkers; Biosensing Techniques; Biosensors; blood serum; Carcinoma, Hepatocellular - diagnosis; Chemistry; detection limit; early diagnosis; Fluorescence; Fluorescent Dyes - chemistry; Gold; Gold - chemistry; Hepatectomy; Hepatocellular carcinoma; hepatoma; Humans; Interference; Limit of Detection; Liver cancer; Liver Neoplasms - diagnosis; Metal Nanoparticles - chemistry; microRNA; MicroRNAs; miRNA; Nanostructures; prediction; prognosis; Raman spectra; Reproducibility; Reproducibility of Results; Spectrum Analysis, Raman; Substrates; Target detection

Ultra-sensitive detection of cancer-related biomarkers in serum is of great significance for early diagnosis, treatment, prognosis, and staging of cancer. In this work, we proposed a surface-enhanced Raman scattering and fluorescence (SERS/FL) dual-mode biosensor for hepatocellular carcinoma (HCC)-r...