Nanolantern-Based DNA Probe and Signal Amplifier for Tumor-Related Biomarker Detection in Living Cells

• Published in: Analytical chemistry (Washington) Vol. 91; no. 20; pp. 13165 - 13173
• Main Authors: Wang, Dong-Xia, Wang, Jing, Cui, Yun-Xi, Wang, Ya-Xin, Tang, An-Na, Kong, De-Ming
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 15.10.2019
• Subjects: Amplifiers; Biocompatibility; Biomarkers; Cells (biology); Chemistry; Deoxyribonucleic acid; DNA; DNA probes; Energy transfer; Fluorescence; Fluorescence resonance energy transfer; Gene expression; Hybridization; hybridization chain reaction; image analysis; Internalization; messenger RNA; microRNA; miRNA; mRNA; nanomaterials; Nanostructure; Nanotechnology; Nucleotides; Oligonucleotides; Performance enhancement; Probes; Reaction kinetics; Ribonucleic acid; RNA; Target detection; Tumors

The introduction of nanotechnology can overcome some inherent drawbacks of traditional DNA probes, thus promoting their applications in living cells. Herein, a three-dimensional DNA nanostructure, a DNA nanolantern, was prepared via simple nucleotide hybridization of four short-stranded oligonucleot...