Fmr1 and Nlgn3 knockout rats: novel tools for investigating autism spectrum disorders

• Published in: Behavioral neuroscience Vol. 128; no. 2; p. 103
• Main Authors: Hamilton, Shannon M, Green, Jennie R, Veeraragavan, Surabi, Yuva, Lisa, McCoy, Aaron, Wu, Yumei, Warren, Joe, Little, Lara, Ji, Diana, Cui, Xiaoxia, Weinstein, Edward, Paylor, Richard
• Format: Journal Article
• Language: English
• Published: United States 01.04.2014
• Subjects: Animals; Cell Adhesion Molecules, Neuronal - genetics; Child Development Disorders, Pervasive - genetics; Child Development Disorders, Pervasive - psychology; Disease Models, Animal; Fragile X Mental Retardation Protein - genetics; Male; Membrane Proteins - genetics; Nerve Tissue Proteins - genetics; Rats; Rats, Sprague-Dawley; Rats, Transgenic; Social Behavior

Animal models are critical for gaining insights into autism spectrum disorder (ASD). Despite their apparent advantages to mice for neural studies, rats have not been widely used for disorders of the human CNS, such as ASD, for the lack of convenient genome manipulation tools. Here we describe two of...