Homogeneous Entropy Catalytic-Driven DNA Hydrogel as Strong Signal Blocker for Highly Sensitive Electrochemical Detection of Platelet-Derived Growth Factor
In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of g-C3N4@Au@Fc-NH2 nanomateria...
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| Published in | Analytical chemistry (Washington) Vol. 90; no. 13; pp. 8241 - 8247 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
American Chemical Society
03.07.2018
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| Subjects | |
| Online Access | Get full text |
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| Abstract | In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of g-C3N4@Au@Fc-NH2 nanomaterials as signal tag. First, the good film-forming nanomaterials of g-C3N4@Au@Fc-NH2, containing large numbers of Fc-NH2 with low resistance and high electric conductivity, were directly immobilized on an electrode surface to provide a strong original electrochemical signal, then the DNA hydrogel blocker formed by target-induced homogeneous entropy catalytic amplification was captured onto the modified electrode surface for significantly reducing the electrochemical signal, in which both the efficient conversion of the single protein to large numbers of DNA strands and the amplification of cycling products could doubly improve the detection sensitivity. As a result, the detection limit could reach 3.5 fM at the range of 0.01 pM to 10 nM. The present strategy by integration of a strong signal blocker to sharply reduce the electrochemical signal of signal tag initiates a new thought to realize the highly sensitive detection of biomarkers and possesses potential applications in clinical diagnosis, sensing, and other related subjects. |
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| AbstractList | In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of g-C
N
@Au@Fc-NH
nanomaterials as signal tag. First, the good film-forming nanomaterials of g-C
N
@Au@Fc-NH
, containing large numbers of Fc-NH
with low resistance and high electric conductivity, were directly immobilized on an electrode surface to provide a strong original electrochemical signal, then the DNA hydrogel blocker formed by target-induced homogeneous entropy catalytic amplification was captured onto the modified electrode surface for significantly reducing the electrochemical signal, in which both the efficient conversion of the single protein to large numbers of DNA strands and the amplification of cycling products could doubly improve the detection sensitivity. As a result, the detection limit could reach 3.5 fM at the range of 0.01 pM to 10 nM. The present strategy by integration of a strong signal blocker to sharply reduce the electrochemical signal of signal tag initiates a new thought to realize the highly sensitive detection of biomarkers and possesses potential applications in clinical diagnosis, sensing, and other related subjects. In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of g-C3N4@Au@Fc-NH2 nanomaterials as signal tag. First, the good film-forming nanomaterials of g-C3N4@Au@Fc-NH2, containing large numbers of Fc-NH2 with low resistance and high electric conductivity, were directly immobilized on an electrode surface to provide a strong original electrochemical signal, then the DNA hydrogel blocker formed by target-induced homogeneous entropy catalytic amplification was captured onto the modified electrode surface for significantly reducing the electrochemical signal, in which both the efficient conversion of the single protein to large numbers of DNA strands and the amplification of cycling products could doubly improve the detection sensitivity. As a result, the detection limit could reach 3.5 fM at the range of 0.01 pM to 10 nM. The present strategy by integration of a strong signal blocker to sharply reduce the electrochemical signal of signal tag initiates a new thought to realize the highly sensitive detection of biomarkers and possesses potential applications in clinical diagnosis, sensing, and other related subjects. In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of g-C3N4@Au@Fc-NH2 nanomaterials as signal tag. First, the good film-forming nanomaterials of g-C3N4@Au@Fc-NH2, containing large numbers of Fc-NH2 with low resistance and high electric conductivity, were directly immobilized on an electrode surface to provide a strong original electrochemical signal, then the DNA hydrogel blocker formed by target-induced homogeneous entropy catalytic amplification was captured onto the modified electrode surface for significantly reducing the electrochemical signal, in which both the efficient conversion of the single protein to large numbers of DNA strands and the amplification of cycling products could doubly improve the detection sensitivity. As a result, the detection limit could reach 3.5 fM at the range of 0.01 pM to 10 nM. The present strategy by integration of a strong signal blocker to sharply reduce the electrochemical signal of signal tag initiates a new thought to realize the highly sensitive detection of biomarkers and possesses potential applications in clinical diagnosis, sensing, and other related subjects.In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of g-C3N4@Au@Fc-NH2 nanomaterials as signal tag. First, the good film-forming nanomaterials of g-C3N4@Au@Fc-NH2, containing large numbers of Fc-NH2 with low resistance and high electric conductivity, were directly immobilized on an electrode surface to provide a strong original electrochemical signal, then the DNA hydrogel blocker formed by target-induced homogeneous entropy catalytic amplification was captured onto the modified electrode surface for significantly reducing the electrochemical signal, in which both the efficient conversion of the single protein to large numbers of DNA strands and the amplification of cycling products could doubly improve the detection sensitivity. As a result, the detection limit could reach 3.5 fM at the range of 0.01 pM to 10 nM. The present strategy by integration of a strong signal blocker to sharply reduce the electrochemical signal of signal tag initiates a new thought to realize the highly sensitive detection of biomarkers and possesses potential applications in clinical diagnosis, sensing, and other related subjects. In this work, an elegantly designed electrochemical biosensor was constructed for platelet-derived growth factor (PDGF) detection based on homogeneous entropy catalytic-induced DNA hydrogel as a strong signal blocker to significantly inhibit the electrochemical signal of g-C₃N₄@Au@Fc-NH₂ nanomaterials as signal tag. First, the good film-forming nanomaterials of g-C₃N₄@Au@Fc-NH₂, containing large numbers of Fc-NH₂ with low resistance and high electric conductivity, were directly immobilized on an electrode surface to provide a strong original electrochemical signal, then the DNA hydrogel blocker formed by target-induced homogeneous entropy catalytic amplification was captured onto the modified electrode surface for significantly reducing the electrochemical signal, in which both the efficient conversion of the single protein to large numbers of DNA strands and the amplification of cycling products could doubly improve the detection sensitivity. As a result, the detection limit could reach 3.5 fM at the range of 0.01 pM to 10 nM. The present strategy by integration of a strong signal blocker to sharply reduce the electrochemical signal of signal tag initiates a new thought to realize the highly sensitive detection of biomarkers and possesses potential applications in clinical diagnosis, sensing, and other related subjects. |
| Author | Li, Mengyao Chai, Yaqin Xiao, Qi Chang, Yuanyuan Zhuo, Ying Wu, Zhongyu Yuan, Ruo |
| AuthorAffiliation | Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering Guangxi Teachers Education University College of Chemistry and Materials Science |
| AuthorAffiliation_xml | – name: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering – name: College of Chemistry and Materials Science – name: Guangxi Teachers Education University |
| Author_xml | – sequence: 1 givenname: Yuanyuan surname: Chang fullname: Chang, Yuanyuan organization: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering – sequence: 2 givenname: Mengyao surname: Li fullname: Li, Mengyao organization: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering – sequence: 3 givenname: Zhongyu surname: Wu fullname: Wu, Zhongyu organization: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering – sequence: 4 givenname: Ying orcidid: 0000-0002-4491-1186 surname: Zhuo fullname: Zhuo, Ying organization: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering – sequence: 5 givenname: Yaqin surname: Chai fullname: Chai, Yaqin organization: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering – sequence: 6 givenname: Qi surname: Xiao fullname: Xiao, Qi email: qi.xiao@whu.edu.cn organization: Guangxi Teachers Education University – sequence: 7 givenname: Ruo orcidid: 0000-0003-3664-6236 surname: Yuan fullname: Yuan, Ruo email: yuanruo@swu.edu.cn organization: Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29874908$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Amplification Analytical chemistry Biomarkers Biosensors Blood platelets Carbon nitride Catalysis Chemistry Deoxyribonucleic acid detection limit DNA electrical conductivity Electrical resistivity Electrochemical analysis Electrochemistry Electrodes Entropy Growth factors Hydrogels Low resistance Nanomaterials Nanotechnology Platelet-derived growth factor Proteins Sensors |
| Title | Homogeneous Entropy Catalytic-Driven DNA Hydrogel as Strong Signal Blocker for Highly Sensitive Electrochemical Detection of Platelet-Derived Growth Factor |
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