Predictive In Vitro Vitreous and Serum Models and Methods to Assess Thiol-Related Quality Attributes in Protein Therapeutics - Liu, Y. Diana; Chen, Yan; Tsui, George; Wei, Bingchuan; Yang, Feng; Yu, Christopher; Cornell, Christopher (Analytical chemistry (Washington), 2020)
Keywords: Analytical chemistry; Animals; Antibodies; Antibodies, Monoclonal - metabolism; biopharmaceuticals; blood serum; Chemistry; Computer simulation; Glutathione; Glutathione - metabolism; humans; Intravenous administration; intravenous injection; Models, Biological; oxidation; Oxidation-Reduction; Physiology; Product quality; Product safety; Proteins; Quality assessment; Quality management; Rabbits; Redox potential; Sulfhydryl Compounds - analysis; Sulfhydryl Compounds - metabolism; Thiols