In Vivo Quantitative Assessment of a Radiation Dose Based on Ratiometric Photoacoustic Imaging of Tumor Apoptosis

• Published in: Analytical chemistry (Washington) Vol. 94; no. 12; pp. 5149 - 5158
• Main Authors: Fang, Jing, Zhao, Yan, Wang, Anna, Zhang, Yuqi, Cui, Chaoxiang, Ye, Shuyue, Mao, Qiulian, Feng, Yali, Li, Jiachen, Xu, Chenjie, Shi, Haibin
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 29.03.2022
• Subjects: analytical chemistry; Apoptosis; Apoptosis - radiation effects; Caspase 3; Chemistry; Dose-Response Relationship, Radiation; Dosimeters; Fluorescence; fluorescent dyes; Humans; neoplasm cells; neoplasms; Neoplasms - diagnostic imaging; Neoplasms - radiotherapy; Optical Imaging; Optimization; Peptides; Photoacoustic Techniques; Radiation; Radiation dosage; Radiation effects; Radiation measurement; Radiation therapy; radiotherapy; Side effects; Therapeutic applications; Tumors

Accurately assessing the radiation level of tumors and surrounding tissues is of great significance for the optimization of clinical therapeutic interventions as well as minimizing the radiation-induced side effects. Therefore, the development of noninvasive and sensitive biological dosimeters is vi...