pH/Reduction Dual Stimuli-Triggered Self-Assembly of NIR Theranostic Probes for Enhanced Dual-Modal Imaging and Photothermal Therapy of Tumors

Tumor microenvironment plays a pivotal role in the growth and metastasis of tumors, and has become a promising target for precise diagnosis and treatment of tumors. Herein, a novel smart NIR theranostic probe Cy-1 that can simultaneously respond to low intracellular pH and reductive glutathione (GSH...

Full description

Saved in:
Bibliographic Details
Published inAnalytical chemistry (Washington) Vol. 92; no. 24; pp. 16113 - 16121
Main Authors Wang, Anna, Mao, Qiulian, Zhao, Meng, Ye, Shuyue, Fang, Jing, Cui, Chaoxiang, Zhao, Yan, Zhang, Yuqi, Zhang, Yu, Zhou, Feng, Shi, Haibin
Format Journal Article
LanguageEnglish
Published United States American Chemical Society 15.12.2020
Subjects
analytical chemistry
Animals
Cell Line, Tumor
Chemistry
condensation reactions
Diagnostic Imaging - methods
Glutathione
Glutathione - metabolism
Humans
Hydrogen-Ion Concentration
Infrared Rays
Medical imaging
Metastases
metastasis
Mice
Molecular Probes - chemistry
Molecular Probes - metabolism
neoplasms
pH effects
Photoacoustic Techniques
Photothermal Therapy - methods
photothermotherapy
Precision medicine
Self-assembly
Stimuli
Tumor Microenvironment
Tumors
Online AccessGet full text

Cover

Abstract Tumor microenvironment plays a pivotal role in the growth and metastasis of tumors, and has become a promising target for precise diagnosis and treatment of tumors. Herein, a novel smart NIR theranostic probe Cy-1 that can simultaneously respond to low intracellular pH and reductive glutathione (GSH) is reported. This probe has demonstrated to be able to intermolecularly undergo a biologically compatible CBT-Cys condensation reaction to selectively form large nanoaggregates in the tumor microenvironment resulting in its enhanced accumulation and retention in the tumor, which as a consequence significantly improves the sensitivity of NIR/photoacoustic imaging and photothermal therapeutic efficacy of tumors in living mice. We thus believe that this dual stimuli-mediated self-assembly strategy may offer a promising and universal platform for cancer theranostics.
AbstractList Tumor microenvironment plays a pivotal role in the growth and metastasis of tumors, and has become a promising target for precise diagnosis and treatment of tumors. Herein, a novel smart NIR theranostic probe Cy-1 that can simultaneously respond to low intracellular pH and reductive glutathione (GSH) is reported. This probe has demonstrated to be able to intermolecularly undergo a biologically compatible CBT-Cys condensation reaction to selectively form large nanoaggregates in the tumor microenvironment resulting in its enhanced accumulation and retention in the tumor, which as a consequence significantly improves the sensitivity of NIR/photoacoustic imaging and photothermal therapeutic efficacy of tumors in living mice. We thus believe that this dual stimuli-mediated self-assembly strategy may offer a promising and universal platform for cancer theranostics.
Tumor microenvironment plays a pivotal role in the growth and metastasis of tumors, and has become a promising target for precise diagnosis and treatment of tumors. Herein, a novel smart NIR theranostic probe Cy-1 that can simultaneously respond to low intracellular pH and reductive glutathione (GSH) is reported. This probe has demonstrated to be able to intermolecularly undergo a biologically compatible CBT-Cys condensation reaction to selectively form large nanoaggregates in the tumor microenvironment resulting in its enhanced accumulation and retention in the tumor, which as a consequence significantly improves the sensitivity of NIR/photoacoustic imaging and photothermal therapeutic efficacy of tumors in living mice. We thus believe that this dual stimuli-mediated self-assembly strategy may offer a promising and universal platform for cancer theranostics.Tumor microenvironment plays a pivotal role in the growth and metastasis of tumors, and has become a promising target for precise diagnosis and treatment of tumors. Herein, a novel smart NIR theranostic probe Cy-1 that can simultaneously respond to low intracellular pH and reductive glutathione (GSH) is reported. This probe has demonstrated to be able to intermolecularly undergo a biologically compatible CBT-Cys condensation reaction to selectively form large nanoaggregates in the tumor microenvironment resulting in its enhanced accumulation and retention in the tumor, which as a consequence significantly improves the sensitivity of NIR/photoacoustic imaging and photothermal therapeutic efficacy of tumors in living mice. We thus believe that this dual stimuli-mediated self-assembly strategy may offer a promising and universal platform for cancer theranostics.
Author Zhao, Meng
Fang, Jing
Shi, Haibin
Zhou, Feng
Zhang, Yuqi
Cui, Chaoxiang
Zhang, Yu
Mao, Qiulian
Wang, Anna
Zhao, Yan
Ye, Shuyue
AuthorAffiliation State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
Department of Radiology
Department of Urology
AuthorAffiliation_xml – name: Department of Radiology
– name: Department of Urology
– name: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
Author_xml – sequence: 1
  givenname: Anna
  surname: Wang
  fullname: Wang, Anna
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 2
  givenname: Qiulian
  surname: Mao
  fullname: Mao, Qiulian
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 3
  givenname: Meng
  surname: Zhao
  fullname: Zhao, Meng
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 4
  givenname: Shuyue
  surname: Ye
  fullname: Ye, Shuyue
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 5
  givenname: Jing
  surname: Fang
  fullname: Fang, Jing
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 6
  givenname: Chaoxiang
  surname: Cui
  fullname: Cui, Chaoxiang
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 7
  givenname: Yan
  surname: Zhao
  fullname: Zhao, Yan
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 8
  givenname: Yuqi
  surname: Zhang
  fullname: Zhang, Yuqi
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
– sequence: 9
  givenname: Yu
  surname: Zhang
  fullname: Zhang, Yu
  organization: Department of Radiology
– sequence: 10
  givenname: Feng
  surname: Zhou
  fullname: Zhou, Feng
  organization: Department of Urology
– sequence: 11
  givenname: Haibin
  orcidid: 0000-0003-2234-9126
  surname: Shi
  fullname: Shi, Haibin
  email: hbshi@suda.edu.cn
  organization: State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33275417$$D View this record in MEDLINE/PubMed
BookMark eNqFkcFO3DAURa0KVAbaP6gqS910k-HZjh1Pd4jSMhK0CKbryHFeZowSe7CTBT_Rb27CDCxYlJUX75wrS-eYHPjgkZBPDOYMODs1Ns2NN63dYDcHC0IDvCMzJjlkSmt-QGYAIDJeAByR45TuARgDpt6TIyF4IXNWzMjf7eXpLdaD7V3w9PtgWnrXu25oXbaKbr3GiDW9w7bJzlLCrmofaWjor-UtXW0wGh9S7yy9iaHCRJsQ6YXfGG9HadrKrkM9Li47s3Z-TY2v6c0m9KEf3W48PG1snyZXQxdi-kAOG9Mm_Lh_T8ifHxer88vs6vfP5fnZVWZyWPSZqBUzlS6sqY3GhdILKZVGWcmFtZViqJky0OiikSC4qIVGtIZVUCheYc3ECfm6293G8DBg6svOJYttazyGIZVc8pxrqXP9NpqrQrGFgmJEv7xC78MQx0YTVQgugeuJ-rynhqrDutxG15n4WD5HGYF8B9gYUorYvCAMyql9ObYvn9uX-_aj9u2VZl1vpq59NK59S4adPF1ffv1f5R86nckk
CitedBy_id crossref_primary_10_1002_adfm_202205385
crossref_primary_10_1016_j_ccr_2023_215600
crossref_primary_10_1039_D4CC02565B
crossref_primary_10_1021_acsbiomaterials_4c00897
crossref_primary_10_1021_acs_nanolett_4c01364
crossref_primary_10_1002_anbr_202300137
crossref_primary_10_1016_j_biochi_2022_09_015
crossref_primary_10_1021_acs_jmedchem_2c00399
crossref_primary_10_1002_anie_202114766
crossref_primary_10_1039_D2CS00673A
crossref_primary_10_1039_D1TB02862F
crossref_primary_10_1021_acs_analchem_2c00098
crossref_primary_10_1002_INMD_20220005
crossref_primary_10_1021_acs_jmedchem_4c02679
crossref_primary_10_1039_D1CC02116H
crossref_primary_10_1021_acs_chemrev_1c00875
crossref_primary_10_1021_acs_bioconjchem_4c00572
crossref_primary_10_1021_acs_chemrev_3c00778
crossref_primary_10_1039_D4CC05494F
crossref_primary_10_1002_ange_202114766
crossref_primary_10_1002_VIW_20220065
crossref_primary_10_1002_adfm_202300340
crossref_primary_10_1002_adsr_202200075
crossref_primary_10_1039_D2QM01207C
crossref_primary_10_1002_adhm_202300153
crossref_primary_10_1016_j_jphotochem_2025_116263
crossref_primary_10_1021_acs_analchem_2c01790
crossref_primary_10_1021_acs_bioconjchem_4c00128
crossref_primary_10_1021_acssensors_2c02129
crossref_primary_10_1016_j_snb_2022_132522
crossref_primary_10_1039_D2CC07008A
Cites_doi 10.1021/acs.nanolett.8b02286
10.1021/acs.nanolett.0c00047
10.1002/anie.201007018
10.1002/adma.201604894
10.1200/JCO.2012.45.3605
10.1038/219697a0
10.1021/nn403664n
10.1002/adma.201505681
10.1016/S1357-4310(99)01615-9
10.1038/s41467-018-05113-8
10.1158/1078-0432.CCR-14-0990
10.1039/C8NR05061A
10.1021/acsnano.9b08209
10.1021/jacs.5b06181
10.1021/jacs.8b10542
10.1002/adma.201703444
10.1182/blood.V97.2.393
10.1101/gad.1047403
10.1039/C3OB41241E
10.1039/C9NR10720G
10.1038/s41563-019-0503-4
10.1038/nrc3110
10.1002/adbi.201800108
10.1002/anie.201908185
10.1021/jacs.6b00073
10.1126/science.1216210
10.1007/978-3-319-91287-5_27
10.1038/nchem.480
10.1039/D0SC02925D
10.1021/jacs.0c00659
10.1002/adma.201605021
10.1021/ja512293f
10.1021/jacs.8b13628
10.1038/ncomms2040
10.1038/nm.3641
10.1148/radiology.219.2.r01ma19316
10.1038/nchem.1920
10.1002/anie.201916352
10.3322/caac.21590
10.1021/jacs.9b09043
10.1002/adfm.201903860
10.1111/j.1440-1843.2009.01703.x
10.1002/adma.201701095
10.1021/acs.accounts.8b00195
10.1038/s41467-019-12848-5
10.1016/j.addr.2012.01.002
10.1007/BF00055376
10.1021/acs.nanolett.8b05154
10.1038/nm.2472
10.1016/j.bbcan.2009.11.002
10.1021/acsnano.7b01026
10.1093/nsr/nwx062
10.1002/hed.20579
10.1158/0008-5472.CAN-09-3197
ContentType Journal Article
Copyright 2020 American Chemical Society
Copyright American Chemical Society Dec 15, 2020
Copyright_xml – notice: 2020 American Chemical Society
– notice: Copyright American Chemical Society Dec 15, 2020
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7TM
7U5
7U7
7U9
8BQ
8FD
C1K
F28
FR3
H8D
H8G
H94
JG9
JQ2
KR7
L7M
L~C
L~D
P64
7X8
7S9
L.6
DOI 10.1021/acs.analchem.0c03800
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Aluminium Industry Abstracts
Biotechnology Research Abstracts
Ceramic Abstracts
Computer and Information Systems Abstracts
Corrosion Abstracts
Electronics & Communications Abstracts
Engineered Materials Abstracts
Materials Business File
Mechanical & Transportation Engineering Abstracts
Nucleic Acids Abstracts
Solid State and Superconductivity Abstracts
Toxicology Abstracts
Virology and AIDS Abstracts
METADEX
Technology Research Database
Environmental Sciences and Pollution Management
ANTE: Abstracts in New Technology & Engineering
Engineering Research Database
Aerospace Database
Copper Technical Reference Library
AIDS and Cancer Research Abstracts
Materials Research Database
ProQuest Computer Science Collection
Civil Engineering Abstracts
Advanced Technologies Database with Aerospace
Computer and Information Systems Abstracts – Academic
Computer and Information Systems Abstracts Professional
Biotechnology and BioEngineering Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Materials Research Database
Technology Research Database
Computer and Information Systems Abstracts – Academic
Mechanical & Transportation Engineering Abstracts
Nucleic Acids Abstracts
ProQuest Computer Science Collection
Computer and Information Systems Abstracts
Materials Business File
Environmental Sciences and Pollution Management
Aerospace Database
Copper Technical Reference Library
Engineered Materials Abstracts
Biotechnology Research Abstracts
AIDS and Cancer Research Abstracts
Advanced Technologies Database with Aerospace
ANTE: Abstracts in New Technology & Engineering
Civil Engineering Abstracts
Aluminium Industry Abstracts
Virology and AIDS Abstracts
Toxicology Abstracts
Electronics & Communications Abstracts
Ceramic Abstracts
METADEX
Biotechnology and BioEngineering Abstracts
Computer and Information Systems Abstracts Professional
Solid State and Superconductivity Abstracts
Engineering Research Database
Corrosion Abstracts
MEDLINE - Academic
AGRICOLA
AGRICOLA - Academic
DatabaseTitleList AGRICOLA
MEDLINE

MEDLINE - Academic
Materials Research Database
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Engineering
Chemistry
EISSN 1520-6882
EndPage 16121
ExternalDocumentID 33275417
10_1021_acs_analchem_0c03800
b955629550
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID -
.K2
02
1AW
23M
55A
5GY
5RE
5VS
7~N
85S
AABXI
ABFLS
ABMVS
ABOCM
ABPPZ
ABPTK
ABUCX
ABUFD
ACGFS
ACGOD
ACIWK
ACJ
ACNCT
ACPRK
ACS
AEESW
AENEX
AFEFF
AFRAH
ALMA_UNASSIGNED_HOLDINGS
AQSVZ
BAANH
BKOMP
CS3
D0L
DZ
EBS
ED
ED~
F20
F5P
GNL
IH9
IHE
JG
JG~
K2
P2P
PQEST
PQQKQ
ROL
RXW
TAE
TN5
UHB
UI2
UKR
VF5
VG9
VQA
W1F
WH7
X
X6Y
XFK
YZZ
---
-DZ
-~X
.DC
4.4
53G
6J9
AAHBH
AAYXX
ABBLG
ABHFT
ABHMW
ABJNI
ABLBI
ABQRX
ACBEA
ACGFO
ACKOT
ADHLV
AGXLV
AHGAQ
CITATION
CUPRZ
GGK
KZ1
LMP
XSW
ZCA
~02
CGR
CUY
CVF
ECM
EIF
NPM
YIN
7QF
7QO
7QQ
7SC
7SE
7SP
7SR
7TA
7TB
7TM
7U5
7U7
7U9
8BQ
8FD
C1K
F28
FR3
H8D
H8G
H94
JG9
JQ2
KR7
L7M
L~C
L~D
P64
7X8
7S9
L.6
ID FETCH-LOGICAL-a409t-3d61ab87cada8e96895568e5b59ccb61e816a0f87f50323d38eeca1b0762bed13
IEDL.DBID ACS
ISSN 0003-2700
1520-6882
IngestDate Fri Jul 11 10:29:41 EDT 2025
Fri Jul 11 11:40:24 EDT 2025
Mon Jun 30 08:21:17 EDT 2025
Wed Feb 19 02:29:15 EST 2025
Tue Jul 01 01:19:16 EDT 2025
Thu Apr 24 23:10:29 EDT 2025
Thu Dec 17 03:36:47 EST 2020
IsPeerReviewed true
IsScholarly true
Issue 24
Language English
License https://doi.org/10.15223/policy-029
https://doi.org/10.15223/policy-037
https://doi.org/10.15223/policy-045
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-a409t-3d61ab87cada8e96895568e5b59ccb61e816a0f87f50323d38eeca1b0762bed13
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0003-2234-9126
PMID 33275417
PQID 2473250287
PQPubID 45400
PageCount 9
ParticipantIDs proquest_miscellaneous_2524285848
proquest_miscellaneous_2467619607
proquest_journals_2473250287
pubmed_primary_33275417
crossref_primary_10_1021_acs_analchem_0c03800
crossref_citationtrail_10_1021_acs_analchem_0c03800
acs_journals_10_1021_acs_analchem_0c03800
ProviderPackageCode JG~
55A
AABXI
GNL
VF5
7~N
ACJ
VG9
W1F
ACS
AEESW
AFEFF
.K2
ABMVS
ABUCX
IH9
BAANH
AQSVZ
ED~
UI2
CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2020-12-15
PublicationDateYYYYMMDD 2020-12-15
PublicationDate_xml – month: 12
  year: 2020
  text: 2020-12-15
  day: 15
PublicationDecade 2020
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Washington
PublicationTitle Analytical chemistry (Washington)
PublicationTitleAlternate Anal. Chem
PublicationYear 2020
Publisher American Chemical Society
Publisher_xml – name: American Chemical Society
References ref9/cit9
ref45/cit45
ref3/cit3
ref27/cit27
ref56/cit56
ref16/cit16
ref52/cit52
ref23/cit23
ref8/cit8
ref31/cit31
ref2/cit2
ref34/cit34
ref37/cit37
ref20/cit20
ref48/cit48
ref17/cit17
ref10/cit10
ref35/cit35
ref53/cit53
ref19/cit19
ref21/cit21
ref42/cit42
ref46/cit46
ref49/cit49
ref13/cit13
ref24/cit24
ref38/cit38
ref50/cit50
ref54/cit54
ref6/cit6
ref18/cit18
Höckel M. (ref36/cit36) 1996; 56
ref11/cit11
ref25/cit25
ref29/cit29
ref32/cit32
ref39/cit39
ref14/cit14
ref5/cit5
ref51/cit51
ref43/cit43
ref28/cit28
ref40/cit40
ref26/cit26
ref55/cit55
ref12/cit12
ref15/cit15
ref41/cit41
ref22/cit22
ref33/cit33
ref4/cit4
ref30/cit30
ref47/cit47
ref1/cit1
ref44/cit44
ref7/cit7
References_xml – ident: ref50/cit50
  doi: 10.1021/acs.nanolett.8b02286
– ident: ref14/cit14
  doi: 10.1021/acs.nanolett.0c00047
– ident: ref41/cit41
  doi: 10.1002/anie.201007018
– ident: ref12/cit12
  doi: 10.1002/adma.201604894
– volume: 56
  start-page: 4509
  year: 1996
  ident: ref36/cit36
  publication-title: Cancer Res.
– ident: ref4/cit4
  doi: 10.1200/JCO.2012.45.3605
– ident: ref26/cit26
  doi: 10.1038/219697a0
– ident: ref37/cit37
  doi: 10.1021/nn403664n
– ident: ref30/cit30
  doi: 10.1002/adma.201505681
– ident: ref29/cit29
  doi: 10.1016/S1357-4310(99)01615-9
– ident: ref17/cit17
  doi: 10.1038/s41467-018-05113-8
– ident: ref3/cit3
  doi: 10.1158/1078-0432.CCR-14-0990
– ident: ref54/cit54
  doi: 10.1039/C8NR05061A
– ident: ref51/cit51
  doi: 10.1021/acsnano.9b08209
– ident: ref38/cit38
  doi: 10.1021/jacs.5b06181
– ident: ref40/cit40
  doi: 10.1021/jacs.8b10542
– ident: ref16/cit16
  doi: 10.1002/adma.201703444
– ident: ref33/cit33
  doi: 10.1182/blood.V97.2.393
– ident: ref5/cit5
  doi: 10.1101/gad.1047403
– ident: ref46/cit46
  doi: 10.1039/C3OB41241E
– ident: ref56/cit56
  doi: 10.1039/C9NR10720G
– ident: ref15/cit15
  doi: 10.1038/s41563-019-0503-4
– ident: ref52/cit52
  doi: 10.1038/nrc3110
– ident: ref18/cit18
  doi: 10.1002/adbi.201800108
– ident: ref49/cit49
  doi: 10.1002/anie.201908185
– ident: ref23/cit23
  doi: 10.1021/jacs.6b00073
– ident: ref55/cit55
  doi: 10.1126/science.1216210
– ident: ref34/cit34
  doi: 10.1007/978-3-319-91287-5_27
– ident: ref42/cit42
  doi: 10.1038/nchem.480
– ident: ref9/cit9
  doi: 10.1039/D0SC02925D
– ident: ref10/cit10
  doi: 10.1021/jacs.0c00659
– ident: ref20/cit20
  doi: 10.1002/adma.201605021
– ident: ref22/cit22
  doi: 10.1021/ja512293f
– ident: ref11/cit11
  doi: 10.1021/jacs.8b13628
– ident: ref39/cit39
  doi: 10.1038/ncomms2040
– ident: ref7/cit7
  doi: 10.1038/nm.3641
– ident: ref6/cit6
  doi: 10.1148/radiology.219.2.r01ma19316
– ident: ref43/cit43
  doi: 10.1038/nchem.1920
– ident: ref44/cit44
  doi: 10.1002/anie.201916352
– ident: ref1/cit1
  doi: 10.3322/caac.21590
– ident: ref19/cit19
  doi: 10.1021/jacs.9b09043
– ident: ref45/cit45
  doi: 10.1002/adfm.201903860
– ident: ref32/cit32
  doi: 10.1111/j.1440-1843.2009.01703.x
– ident: ref13/cit13
  doi: 10.1002/adma.201701095
– ident: ref28/cit28
  doi: 10.1021/acs.accounts.8b00195
– ident: ref48/cit48
  doi: 10.1038/s41467-019-12848-5
– ident: ref53/cit53
  doi: 10.1038/nchem.480
– ident: ref24/cit24
  doi: 10.1016/j.addr.2012.01.002
– ident: ref35/cit35
  doi: 10.1007/BF00055376
– ident: ref47/cit47
  doi: 10.1021/acs.nanolett.8b05154
– ident: ref8/cit8
  doi: 10.1038/nm.2472
– ident: ref2/cit2
  doi: 10.1016/j.bbcan.2009.11.002
– ident: ref21/cit21
  doi: 10.1021/acsnano.7b01026
– ident: ref27/cit27
  doi: 10.1093/nsr/nwx062
– ident: ref31/cit31
  doi: 10.1002/hed.20579
– ident: ref25/cit25
  doi: 10.1158/0008-5472.CAN-09-3197
SSID ssj0011016
Score 2.4890857
Snippet Tumor microenvironment plays a pivotal role in the growth and metastasis of tumors, and has become a promising target for precise diagnosis and treatment of...
SourceID proquest
pubmed
crossref
acs
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 16113
SubjectTerms analytical chemistry
Animals
Cell Line, Tumor
Chemistry
condensation reactions
Diagnostic Imaging - methods
Glutathione
Glutathione - metabolism
Humans
Hydrogen-Ion Concentration
Infrared Rays
Medical imaging
Metastases
metastasis
Mice
Molecular Probes - chemistry
Molecular Probes - metabolism
neoplasms
pH effects
Photoacoustic Techniques
Photothermal Therapy - methods
photothermotherapy
Precision medicine
Self-assembly
Stimuli
Tumor Microenvironment
Tumors
Title pH/Reduction Dual Stimuli-Triggered Self-Assembly of NIR Theranostic Probes for Enhanced Dual-Modal Imaging and Photothermal Therapy of Tumors
URI http://dx.doi.org/10.1021/acs.analchem.0c03800
https://www.ncbi.nlm.nih.gov/pubmed/33275417
https://www.proquest.com/docview/2473250287
https://www.proquest.com/docview/2467619607
https://www.proquest.com/docview/2524285848
Volume 92
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELagHIADj_JaKMhIXDh4G9uJ7RyrpdUWqaXqplJvK7_SIjZJ1SQH-BH8Zjx5bHmoFK6xPYnHdvyNx_MNQu9Y7lLrlSeUx5zE0iTEOEeJlSJXMY28iSF2-OBQzE_ij6fJ6ZWh-LsHn9FtbeupDkoNfSimkY14gDi30R0mlARja2e2WHsNwBIdM-SBQ3UMlbtGCmxItv51Q7oGZXa7zd5D9GmM2ekvmXyZto2Z2m9_Ujj-Y0ceoQcD8MQ7_Ux5jG75chPdnY353jbR_Z-oCZ-g7xfz7WOgdYWBwx_a0HTRfIa7VCQLBv0ZpPjEC7_KCbiNC7P6iqscH-4f4wwiusoK-J_xEQQb1TgAY7xbnneXDTpZ5KByQeJ-0eVIwrp0-Oi8arposCIUZD3XAYjM2qK6rJ-ik73dbDYnQ-4GooPF2BDuBNVGSaudVj4VKgWqM5-YJLXWCOoVFTrKlcyTiDPuuPLeamqi8HM23lH-DG2UVelfIMxiY6iRCrjxYu6kFkLnaQ7v8VpSPUHvg2qXw9qrl51bndElPBz1vRz0PUF8HOylHUjQIRfH6oZWZN3qoicBuaH-1jiPrj6LxZIHvBks1Al6uy4OYwweGl36qoU6Ao6VRPS3OklAVSrgRjVBz_s5uv4ozplMYipf_odKXqF7DM4QKCM02UIbzWXrXweg1Zg33er6Aa6CJYg
linkProvider American Chemical Society
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Lb9QwELZKOZQeeJTXQgEjceHgbRwnjnOslla70F1V3RT1FvkVirpJqiY5wI_gN-PJJikglapXx544Yzv-xuP5BqEPfmZibYUllAWMBJEKiTKGEh3xTATUsyqA2OH5gk9Pg89n4dkGCvtYGNeJykmqWif-NbsA3YMy6XTrPiUfe9pjDuncQ_cdHvHB5tqfLAfnARikfaI88Kv2EXM3SIF9SVd_70s3gM120zl8hL4O3W3vmlyMm1qN9c9_mBzv_D2P0cMOhuL99bx5gjZssYO2Jn32tx20_QdR4VP063K6dwIkrzCM-FPjmi7r73CziiTOvP8GCT_x0q4yAk7kXK1-4DLDi9kJTiC-qyiBDRofQ-hRhR1MxgfFeXv1oJVF5qVxEmd5mzEJy8Lg4_OybmPDcvcgWTMfgMikycur6hk6PTxIJlPSZXIg0tmPNWGGU6lEpKWRwsZcxEB8ZkMVxlorTq2gXHqZiLLQYz4zTFirJVWe-1Urayh7jjaLsrAvEfYDpaiKBDDlBcxEknOZxRm8x8qIyhH66FSbdiuxSlsnu09TKOz1nXb6HiHWj3mqO0p0yMyxuqUVGVpdrilBbqm_20-n6275QcQc-nT26gi9Hx67MQZ_jSxs2UAdDodM3PtfndBhLOFQpBihF-upOnSKMT8KAxq9uoNK3qGtaTI_So9miy-v0QMfTheoT2i4izbrq8a-cRCsVm_bBfcbroMt6Q
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9QwELagSDwOPEopCwWMxIWDt3GcxM6x2na1C3S16m6likvkVyjqJlk1yQF-BL8ZTzYJBalUcPVjMh7b8YzH8w1C7_zUxNoKSygLGAm4CokyhhLNo1QE1LMqgNjh41k0OQ0-nIVnV1J9OSZKR6lsnPiwq9cmbREG6D6USydfN5xs6GmPOW3nNroDnjuwuw5Gi96BAEZplywPfKtd1Nw1VOBs0uXvZ9M1Cmdz8Iwfoc89y817k4thXamh_v4HmuN_jekxetiqo_hgs36eoFs230b3Rl0WuG304Apg4VP0Yz3ZPwGwV5hOfFi7rovqK7ywIktn5n-BxJ94YVcpAWdyplbfcJHi2fQELyHOKy8AFRrPIQSpxE5dxkf5efMEoaFFjgvjKE6zJnMSlrnB8_OiamLEMlex3CAgAMllnRWX5Q46HR8tRxPSZnQg0tmRFWEmolIJrqWRwsaRiAEAzYYqjLVWEbWCRtJLBU9Dj_nMMGGtllR57petrKHsGdrKi9w-R9gPlKKKC0DMC5jhMopkGqfwHSs5lQP03ok2aXdkmTTOdp8mUNjJO2nlPUCsm_dEt9DokKFjdUMv0vdab6BBbmi_1y2pX2z5AWdOC3V26wC97avdHIPfRua2qKFNBJdNkfe3NqHTtYTTJsUA7W6Wa88UYz4PA8pf_INI3qC788Nx8mk6-_gS3ffhkoH6hIZ7aKu6rO0rp4lV6nWz534CR3IwbA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=pH%2FReduction+Dual+Stimuli-Triggered+Self-Assembly+of+NIR+Theranostic+Probes+for+Enhanced+Dual-Modal+Imaging+and+Photothermal+Therapy+of+Tumors&rft.jtitle=Analytical+chemistry+%28Washington%29&rft.au=Wang%2C+Anna&rft.au=Mao%2C+Qiulian&rft.au=Zhao%2C+Meng&rft.au=Ye%2C+Shuyue&rft.date=2020-12-15&rft.issn=0003-2700&rft.eissn=1520-6882&rft.volume=92&rft.issue=24&rft.spage=16113&rft.epage=16121&rft_id=info:doi/10.1021%2Facs.analchem.0c03800&rft.externalDBID=n%2Fa&rft.externalDocID=10_1021_acs_analchem_0c03800
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0003-2700&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0003-2700&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0003-2700&client=summon