Detection of K+ Efflux from Stimulated Cortical Neurons by an Aptamer-Modified Silicon Nanowire Field-Effect Transistor

• Published in: ACS sensors Vol. 2; no. 1; pp. 69 - 79
• Main Authors: Anand, Ankur, Liu, Chia-Rung, Chou, Ai-Chuan, Hsu, Wan-Hsuan, Ulaganathan, Rajesh Kumar, Lin, Yi-Cheng, Dai, Chi-An, Tseng, Fan-Gang, Pan, Chien-Yuan, Chen, Yit-Tsong
• Format: Journal Article
• Language: English
• Published: United States American Chemical Society 27.01.2017
• Subjects: neuron; biosensor; aptamer; ion channel; potassium ion; silicon nanowire field-effect transistor

The concentration gradient of K+ across the cell membrane of a neuron determines its resting potential and cell excitability. During neurotransmission, the efflux of K+ from the cell via various channels will not only decrease the intracellular K+ content but also elevate the extracellular K+ concen...